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Acute Tubular Necrosis in Infancy and Childhood

AMA Am J Dis Child. 1958;95(4):417-433. doi:10.1001/archpedi.1958.02060050421012.
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Introduction  Acute renal failure is a clinical syndrome characterized by the sudden onset of severe oliguria or anuria followed by the retention of excretory products. It may be due to either reversible or irreversible lesions in the kidneys or urinary passages. In the majority of cases the lesion is reversible, provided an early diagnosis is made and appropriate management is instituted. Cases which prove to be irreversible may be very difficult to diagnose as such during life, particularly during the early course of the syndrome, and consequently they often merit essentially the same plan of management as the former group.Acute tubular necrosis is now recognized as an important cause of acute reversible renal failure. For many years the existence of acute renal failure due to a variety of different etiological agents had been recognized.1 During the past 15 years, it has been established that degeneration in the epithelium


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