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Encephalitis Complicating Attenuated Rubeola

AMA Am J Dis Child. 1958;95(3):270-275. doi:10.1001/archpedi.1958.02060050272007.
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The value of γ-globulin in preventing or modifying measles has been clearly demonstrated.1 There is also considerable evidence to indicate that modified rubeola is a comparatively mild disease, usually unaccompanied by significant complications.1,2 Only three cases of encephalitis following measles attenuated by γ-globulin have appeared in the literature.3,4,7 Holliday5 refers to two possible instances but states that in neither could a definite diagnosis be made. Gellis6 has information on 10 cases of encephalitis associated with attenuated measles from his own experience and from reports to him from other physicians. However, the diagnosis in all of the reported cases has been based on clinical grounds alone, with no pathological confirmation. It is the purpose of this communication to report two cases of encephalitis complicating rubeola attenuated by gamma globulin. One, that of a child who died on the 36th hospital day with empyema, bronchopneumonia, perforation of


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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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