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The Prompt and Effective Response of Trichinosis to Corticotropin FREE

NATHAN M. GREENSTEIN, M.D.; DAVID STEINBERG, M.D.
[+] Author Affiliations

Received for publication Aug. 30, 1957; revised Oct. 17; accepted Nov. 4.

Personal communication from Dr. James H. Steele, chief of the Veterinary Health Section of the U. S. Public Health Service, Atlanta.


AMA Am J Dis Child. 1958;95(3):261-269. doi:10.1001/archpedi.1958.02060050263006.
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Trichinosis is one of the most ubiquitous diseases of infectious origin. It has been estimated that 1 in every 6 persons in the United States, about 25,000,000, harbor the causative agent, Trichinella spiralis.1 Each year 350,000 more acquire the infection and almost 16,000 may ingest enough parasites to produce detectable signs and symptoms. It is further estimated that about 5% of all those with symptomatic infection die, although many of these cases are undiagnosed, unrecognized, or unreported.* The average annual number of reported cases is about 336.

In a nation which becomes palpably distressed by public discussion of diseases of much lower incidence, these figures should arouse a tremendous demand for correction of a shocking situation. Ironically, the means for control and prevention are readily available. Supervision of distribution of pork and pork products should, if properly conducted, go far in eliminating trichinosis. Unfortunately, the high incidence of this

REFERENCES

 Trichinosis , Editorials, J. A. M. A. 152:241 ( (May 16) ) 1953;.
Belding, D. L.: Textbook of Clinical Parasitology , New York, Appleton-Century-Crofts, Inc., 1952;.
Davis, W. M., and Most, H.:  Trichinosis , Am. J. Med. 11:639 ( (Nov.) ) 1951;.
Rothenberg, F.:  Treatment of Trichinosis with Cortisone , J. M. Soc. New Jersey , 48:517 ( (Nov.) ) 1951;.
Luongo, M. A.; Reid, D. H., and Weiss, W. W.:  The Effect of ACTH in Trichinosis , New England J. Med. 245:157 ( (Nov. 15) ) 1951;.
Rosen, E.:  Cortisone Treatment of Trichinosis , Am. J. M. Sc. 223:16 ( (Jan.) ) 1952;.
Solomon, C., and Seligman, B.:  Response of Trichiniasis to Adrenocorticotropic Hormone (ACTH) Therapy , New York J. Med. 52:1444 ( (June 1) ) 1952;.
Buylla, P. A.; Llavona, J. A., and Villaroya, P. F.:  Triquinosis tratado con ACTH , Rev. clin. españ. 49:168 ( (May 15) ) 1953;.
Roehm, D. S.:  Trichinosis , Ann. Int. Med. 40:1026 ( (May) ) 1954;.
Sadusk, J. F.:  Cortisone in the Treatment of Trichinosis , California Med. 81:348 ( (Nov.) ) 1954;.
Wertheim, J. M., and Cohen, S.:  A Case of Trichiniasis Treated with Cortisone , New York J. Med. 55:1908 ( (July 1) ) 1955;.
Segar, L. F.; Kashtan, H. A., and Miller, P. B.:  Trichinosis with Myocarditis , New England J. Med. 252:397 ( (March 10) ) 1955;.
Greenstein, N. M.:  Corticotropin in Rheumatic Carditis: Beneficial Effects of High Dosage and Short Duration in Acute Exacerbations of Chronic Rheumatic Carditis , A. M. A. Am. J. Dis. Child. 87:694 ( (June) ) 1954;.
Ober, R. E.:  Trichinosis , New England J. Med. 235:838 ( (Dec. 12) ) 1946;.
Byers, R. K., and Moll, F. C.:  Encephalopathies Following Prophylactic Pertussis Vaccine , Pediatrics 1:437 ( (April) ) 1948;.
Roett, C. J. E.; Freeman, L. C., and Scott, R. B.:  Incidence of "Subclinical" Trichinosis in Children: Observations Based on Reaction to Intradermal Test with Trichinella Antigen , A. M. A. Am. J. Dis. Child. 87:464 ( (April) ) 1954;.
Coker, C. M.:  Effects of Cortisone on Cellular Inflammation in the Musculature of Mice Given Infection with Trichinella Spiralis , J. Parasitol. 42:479 ( (Oct.) ) 1946;.
Burrage, W. S.; Greene, J. E.; Burgin, L. B.; Itkin, I. H.; Novey, H. S.; Engler, J., and Irwin, J. W.:  Allergy , New England J. Med. 255:79 ( (July 12) ) 1956;.
Harrell, G. T., and Aikawa, J. K.:  Alterations in the Permeability of Membranes During Infections , J.A.M.A. 147:232 ( (Sept. 15) ) 1951;.
Harvey, A. M.; Shulman, L. E., and Schoenrich, E. H., in The Effect of ACTH and Cortisone upon Infection and Resistance, a symposium held at the Academy, March 27-28, 1952, edited by G. Shwartzman, New York Academy of Medicine, Section of Microbiology, New York, Columbia University Press, 1953.
Kern, R. A.:  The Use and Abuse of Steroid Therapy, Notably in Allergic Disorders , Am. J. M. Sc. 233:430 ( (April) ) 1957;.

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References

 Trichinosis , Editorials, J. A. M. A. 152:241 ( (May 16) ) 1953;.
Belding, D. L.: Textbook of Clinical Parasitology , New York, Appleton-Century-Crofts, Inc., 1952;.
Davis, W. M., and Most, H.:  Trichinosis , Am. J. Med. 11:639 ( (Nov.) ) 1951;.
Rothenberg, F.:  Treatment of Trichinosis with Cortisone , J. M. Soc. New Jersey , 48:517 ( (Nov.) ) 1951;.
Luongo, M. A.; Reid, D. H., and Weiss, W. W.:  The Effect of ACTH in Trichinosis , New England J. Med. 245:157 ( (Nov. 15) ) 1951;.
Rosen, E.:  Cortisone Treatment of Trichinosis , Am. J. M. Sc. 223:16 ( (Jan.) ) 1952;.
Solomon, C., and Seligman, B.:  Response of Trichiniasis to Adrenocorticotropic Hormone (ACTH) Therapy , New York J. Med. 52:1444 ( (June 1) ) 1952;.
Buylla, P. A.; Llavona, J. A., and Villaroya, P. F.:  Triquinosis tratado con ACTH , Rev. clin. españ. 49:168 ( (May 15) ) 1953;.
Roehm, D. S.:  Trichinosis , Ann. Int. Med. 40:1026 ( (May) ) 1954;.
Sadusk, J. F.:  Cortisone in the Treatment of Trichinosis , California Med. 81:348 ( (Nov.) ) 1954;.
Wertheim, J. M., and Cohen, S.:  A Case of Trichiniasis Treated with Cortisone , New York J. Med. 55:1908 ( (July 1) ) 1955;.
Segar, L. F.; Kashtan, H. A., and Miller, P. B.:  Trichinosis with Myocarditis , New England J. Med. 252:397 ( (March 10) ) 1955;.
Greenstein, N. M.:  Corticotropin in Rheumatic Carditis: Beneficial Effects of High Dosage and Short Duration in Acute Exacerbations of Chronic Rheumatic Carditis , A. M. A. Am. J. Dis. Child. 87:694 ( (June) ) 1954;.
Ober, R. E.:  Trichinosis , New England J. Med. 235:838 ( (Dec. 12) ) 1946;.
Byers, R. K., and Moll, F. C.:  Encephalopathies Following Prophylactic Pertussis Vaccine , Pediatrics 1:437 ( (April) ) 1948;.
Roett, C. J. E.; Freeman, L. C., and Scott, R. B.:  Incidence of "Subclinical" Trichinosis in Children: Observations Based on Reaction to Intradermal Test with Trichinella Antigen , A. M. A. Am. J. Dis. Child. 87:464 ( (April) ) 1954;.
Coker, C. M.:  Effects of Cortisone on Cellular Inflammation in the Musculature of Mice Given Infection with Trichinella Spiralis , J. Parasitol. 42:479 ( (Oct.) ) 1946;.
Burrage, W. S.; Greene, J. E.; Burgin, L. B.; Itkin, I. H.; Novey, H. S.; Engler, J., and Irwin, J. W.:  Allergy , New England J. Med. 255:79 ( (July 12) ) 1956;.
Harrell, G. T., and Aikawa, J. K.:  Alterations in the Permeability of Membranes During Infections , J.A.M.A. 147:232 ( (Sept. 15) ) 1951;.
Harvey, A. M.; Shulman, L. E., and Schoenrich, E. H., in The Effect of ACTH and Cortisone upon Infection and Resistance, a symposium held at the Academy, March 27-28, 1952, edited by G. Shwartzman, New York Academy of Medicine, Section of Microbiology, New York, Columbia University Press, 1953.
Kern, R. A.:  The Use and Abuse of Steroid Therapy, Notably in Allergic Disorders , Am. J. M. Sc. 233:430 ( (April) ) 1957;.

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