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Isolation of ECHO Virus Type Two from the Cerebrospinal Fluid in Aseptic Meningitis

ALMEN L. BARRON, Ph.D.; DAVID T. KARZON, M.D.; BEATRICE F. POLLOCK, M.S.
AMA Am J Dis Child. 1958;95(3):235-239. doi:10.1001/archpedi.1958.02060050237001.
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The significance of the ECHO (enteric cytopathogenic human orphan) viruses in the etiology of human disease, particularly in the syndrome of aseptic meningitis, is gradually being defined. Of 14 original ECHO virus serotypes, only 6 were isolated from the intestinal tracts of sporadic cases of aseptic meningitis. The remainder were isolated from the intestinal tracts of well persons. The demonstration of the prevalence of ECHO viruses in the healthy population has resulted in a need for more rigorous proof of the etiologic relationship of each serotype with human disease. Such evidence has already been presented for certain ECHO virus types, i. e., ECHO virus Type 6,1 Type 4,2 and Type 9,3 each of which has been studied in epidemic situations. This report concerns the isolation of ECHO virus Type 2 from the cerebrospinal fluids of two related persons with aseptic meningitis in Buffalo and presents evidence for

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