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March 1958, Vol 95, No. 3 >
Article | March 1958

Isolation of ECHO Virus Type Two from the Cerebrospinal Fluid in Aseptic Meningitis FREE

ALMEN L. BARRON, Ph.D.; DAVID T. KARZON, M.D.; BEATRICE F. POLLOCK, M.S.
[+] Author Affiliations

Received for publication Nov. 25, 1957.

The human γ-globulin, Lots 262 and 489, was supplied as a 16.5% preservative-free sterile solution by Lederle Laboratories Division, American Cyanamid Company, Pearl River, N. Y.

This study was aided in part by a grant from the National Foundation for Infantile Paralysis and contracts with the Communicable Disease Center, U. S. P. H. S., Atlanta, and the Erie County (N. Y.) Laboratories.


AMA Am J Dis Child. 1958;95(3):235-239. doi:10.1001/archpedi.1958.02060050237001.
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References
Comments

The significance of the ECHO (enteric cytopathogenic human orphan) viruses in the etiology of human disease, particularly in the syndrome of aseptic meningitis, is gradually being defined. Of 14 original ECHO virus serotypes, only 6 were isolated from the intestinal tracts of sporadic cases of aseptic meningitis. The remainder were isolated from the intestinal tracts of well persons. The demonstration of the prevalence of ECHO viruses in the healthy population has resulted in a need for more rigorous proof of the etiologic relationship of each serotype with human disease. Such evidence has already been presented for certain ECHO virus types, i. e., ECHO virus Type 6,1 Type 4,2 and Type 9,3 each of which has been studied in epidemic situations. This report concerns the isolation of ECHO virus Type 2 from the cerebrospinal fluids of two related persons with aseptic meningitis in Buffalo and presents evidence for

REFERENCES

1 +
Karzon, D. T.; Barron, A. L.; Winkelstein, W., Jr., and Cohen, S.:  Isolation of ECHO Virus Type 6 During Outbreak of Seasonal Aseptic Meningitis , J.A.M.A. 162:1298-1303 ( (Dec.) ) 1956;.
2 +
Chin, T. D. Y.; Beran, G. W., and Wenner, H. A.:  An Epidemic Illness Associated with a Recently Recognized Enteric Virus (ECHO Virus Type 4): II. Recognition and Indentification of the Etiologic Agent , Am. J. Hyg. 66:76-84 ( (July) ) 1957;.
3 +
Tyrrell, D. A. J., and Snell, B.:  Recovery of a Virus from Cases of an Epidemic Exanthem Associated with Aseptic Meningitis , Lancet 2:1028-1029 ( (Nov. 17) ) 1956;.
4 +
Committee on ECHO Viruses,  National Foundation for Infantile Paralysis: Enteric Cytopathogenic Human Orphan (ECHO) Viruses , Science 122:1187-1188 ( (Dec.) ) 1955;.
5 +
Melnick, J. L., in American Public Health Association: Diagnostic Procedures for Virus and Rickettsial Disease , Ed. 2, New York, The Association, 1956;, pp. 91-96.
6 +
Winkelstein, W., Jr.; Karzon, D. T.; Barron, A. L., and Hayner, N. S.:  Epidemiologic Observations on an Outbreak of Aseptic Meningitis Due to ECHO Virus Type 6 , Am. J. Pub. Health 47:741-749 ( (June) ) 1957;.
7 +
Kibrick, S.; Meléndez, L., and Enders, J. F.:  Clinical Associations of Enteric Viruses with Particular Reference to Agents Exhibiting Properties of the ECHO Group , Ann. New York Acad. Sc. 67:311-325 ( (April) ) 1957;.
8 +
Davis, D. C., and Melnick, J. L.:  Association of ECHO Virus Type 6 with Aseptic Meningitis , Proc. Soc. Exper. Biol. & Med. 92:839-843 ( (Aug.) -Sept.) 1956;.
9 +
Meyer, H. M., Jr.; Rogers, N. G.; Miesse, M. L., and Crawford, I. P.:  Aseptic Meningitis Caused by Orphan Viruses and Other Agents , Ann. New York Acad. Sc. 67:332-337 ( (April) ) 1957;.
10 +
Svedmyr, A.:  ECHO Viruses , in Discussion: Part III, Ann. New York Acad. Sc. 67:352-353 ( (April) ) 1957;.
11 +
Karzon, D. T.; Barron, A. L., and Pollock, B. F.: An Epidemic of Aseptic Meningitis Due to an Enteric Virus Related to the ECHO Virus Group, read before the Society for Pediatric Research, Carmel, Calif., June, 1957.
12 +
Boissard, G. P. B.; Stokes, L. J.; Macrae, A. D., and MacCallum, F. O.:  Isolation of Viruses Related to ECHO Virus Type 9 from Outbreaks of Aseptic Meningitis , Lancet 1:500-503 ( (March 9) ) 1957;.
13 +
Baumann, T.; Barben, M.; Marti, R.; Hassler, A., and Krech, U.:  Erkrankangen durch ECHO-Virus Typ 9: Eine epidemiologische, klinische und virologisch-serologische Studie , Schweiz. med. Wchnschr. 87:307-315 ( (March 30) ) 1957;.
14 +
Nihoul, E.; Quersin-Thiry, L., and Weyants, A.:  ECHO Virus Type 9 as the Agent Responsible for an Important Outbreak of Aseptic Meningitis in Belgium , Am. J. Hyg. 66:102-118 ( (July) ) 1957;.
15 +
Rhodes, A. J.: Personal communication to the authors.
16 +
Committee on ECHO Viruses: Personal communication to the authors.
17 +
Steigman, A. J.; Kokko, U. P., and Silverberg, R. J.:  Unusual Properties of a Virus Isolated from the Spinal Cord of a Child with Fatal Poliomyelitis , A.M.A. Am. J. Dis. Child. 86:509-510 ( (Oct.) ) 1953;.
18 +
Kibrick, S.: Personal communication to the authors.
19 +
Ramos-Alvarez, M.:  Cytopathogenic Enteric Viruses Associated with Undifferentiated Diarrheal Syndromes in Early Childhood , Ann. New York Acad. Sc. 67:326-331 ( (April) ) 1957;.
20 +
Wenner, H. A.: Benign Aseptic Meningitis: An Outbreak Caused by ECHO Virus Type 4, read before the 4th International Poliomyelitis Conference, Geneva, Switzerland, July, 1957.

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References

1 +
Karzon, D. T.; Barron, A. L.; Winkelstein, W., Jr., and Cohen, S.:  Isolation of ECHO Virus Type 6 During Outbreak of Seasonal Aseptic Meningitis , J.A.M.A. 162:1298-1303 ( (Dec.) ) 1956;.
2 +
Chin, T. D. Y.; Beran, G. W., and Wenner, H. A.:  An Epidemic Illness Associated with a Recently Recognized Enteric Virus (ECHO Virus Type 4): II. Recognition and Indentification of the Etiologic Agent , Am. J. Hyg. 66:76-84 ( (July) ) 1957;.
3 +
Tyrrell, D. A. J., and Snell, B.:  Recovery of a Virus from Cases of an Epidemic Exanthem Associated with Aseptic Meningitis , Lancet 2:1028-1029 ( (Nov. 17) ) 1956;.
4 +
Committee on ECHO Viruses,  National Foundation for Infantile Paralysis: Enteric Cytopathogenic Human Orphan (ECHO) Viruses , Science 122:1187-1188 ( (Dec.) ) 1955;.
5 +
Melnick, J. L., in American Public Health Association: Diagnostic Procedures for Virus and Rickettsial Disease , Ed. 2, New York, The Association, 1956;, pp. 91-96.
6 +
Winkelstein, W., Jr.; Karzon, D. T.; Barron, A. L., and Hayner, N. S.:  Epidemiologic Observations on an Outbreak of Aseptic Meningitis Due to ECHO Virus Type 6 , Am. J. Pub. Health 47:741-749 ( (June) ) 1957;.
7 +
Kibrick, S.; Meléndez, L., and Enders, J. F.:  Clinical Associations of Enteric Viruses with Particular Reference to Agents Exhibiting Properties of the ECHO Group , Ann. New York Acad. Sc. 67:311-325 ( (April) ) 1957;.
8 +
Davis, D. C., and Melnick, J. L.:  Association of ECHO Virus Type 6 with Aseptic Meningitis , Proc. Soc. Exper. Biol. & Med. 92:839-843 ( (Aug.) -Sept.) 1956;.
9 +
Meyer, H. M., Jr.; Rogers, N. G.; Miesse, M. L., and Crawford, I. P.:  Aseptic Meningitis Caused by Orphan Viruses and Other Agents , Ann. New York Acad. Sc. 67:332-337 ( (April) ) 1957;.
10 +
Svedmyr, A.:  ECHO Viruses , in Discussion: Part III, Ann. New York Acad. Sc. 67:352-353 ( (April) ) 1957;.
11 +
Karzon, D. T.; Barron, A. L., and Pollock, B. F.: An Epidemic of Aseptic Meningitis Due to an Enteric Virus Related to the ECHO Virus Group, read before the Society for Pediatric Research, Carmel, Calif., June, 1957.
12 +
Boissard, G. P. B.; Stokes, L. J.; Macrae, A. D., and MacCallum, F. O.:  Isolation of Viruses Related to ECHO Virus Type 9 from Outbreaks of Aseptic Meningitis , Lancet 1:500-503 ( (March 9) ) 1957;.
13 +
Baumann, T.; Barben, M.; Marti, R.; Hassler, A., and Krech, U.:  Erkrankangen durch ECHO-Virus Typ 9: Eine epidemiologische, klinische und virologisch-serologische Studie , Schweiz. med. Wchnschr. 87:307-315 ( (March 30) ) 1957;.
14 +
Nihoul, E.; Quersin-Thiry, L., and Weyants, A.:  ECHO Virus Type 9 as the Agent Responsible for an Important Outbreak of Aseptic Meningitis in Belgium , Am. J. Hyg. 66:102-118 ( (July) ) 1957;.
15 +
Rhodes, A. J.: Personal communication to the authors.
16 +
Committee on ECHO Viruses: Personal communication to the authors.
17 +
Steigman, A. J.; Kokko, U. P., and Silverberg, R. J.:  Unusual Properties of a Virus Isolated from the Spinal Cord of a Child with Fatal Poliomyelitis , A.M.A. Am. J. Dis. Child. 86:509-510 ( (Oct.) ) 1953;.
18 +
Kibrick, S.: Personal communication to the authors.
19 +
Ramos-Alvarez, M.:  Cytopathogenic Enteric Viruses Associated with Undifferentiated Diarrheal Syndromes in Early Childhood , Ann. New York Acad. Sc. 67:326-331 ( (April) ) 1957;.
20 +
Wenner, H. A.: Benign Aseptic Meningitis: An Outbreak Caused by ECHO Virus Type 4, read before the 4th International Poliomyelitis Conference, Geneva, Switzerland, July, 1957.

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