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Eosinophilic Granuloma

AMA Am J Dis Child. 1958;95(2):214-216. doi:10.1001/archpedi.1958.02060050216015.
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In a recent review of patients treated for reticuloendotheliosis of the nonlipid type, the author1 made note of the apparent increase in frequency of this condition. Our experience at the Children's Memoral Hospital with patients of the Letterer-Siwe and Hand-Schüller-Christian group shows these conditions to be less rare than they once were. This, however, is more likely the result of the referring of youngsters with serious or unusual diseases to a children's hospital rather than of a marked change in the character of the disease. The third member of the group, eosinophilic granuloma, is still most unusual—especially if the skin alone is affected.

Eosinophilic granuloma as it involves the bone is seen frequently enough to be suspected after the viewing of an x-ray picture of the involved site, and the diagnosis may be readily confirmed by a biopsy of the bone. The evaluation of the problem of eosinophilic granuloma


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