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December 1957, Vol 94, No. 6 >
Article | December 1957

Cushing's Syndrome in Infancy FREE

ROBERT B. GREENBLATT, M.D.; JORGE MARTINEZ MANAUTOU, M.D.; A. MARVIN ZIMMERMAN, M.D.; WILLIAM T. LUCAS, M.D.
[+] Author Affiliations

Received for publication May 13, 1957; accepted June 13.

Since calcification was present in the adrenal adenoma, it is quite possible that the process had gone on for more than five months.


AMA Am J Dis Child. 1957;94(6):691-695. doi:10.1001/archpedi.1957.04030070103012.
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References
Comments

Cushing's syndrome in infancy is very rare. Recently, Guin and Gilbert reviewed 28 cases of adrenal cortical carcinoma associated with this syndrome in persons less than 14 years old.1 They added one case, with onset at 6 weeks. In only 2 of the 29 cases did the symptoms appear before the age of 6 months. In reviewing the literature the impression is gained that Cushing's syndrome in the pediatric age group is usually caused by an adrenal tumor. Albright and Forbes were of the opinion that all such cases in infancy are caused by malignant tumors.2 Forsham and Thorn also believed that the adrenal lesion was oftenest a malignant one when the disease appeared before puberty.3 However, Powell cites two instances due to adrenal cortical adenoma within the first year of life.4,5 Furthermore, Talbot et al. claim that bilateral adrenal hyperplasia is more commonly the cause

REFERENCES

1 +
Guin, G. H., and Gilbert, E. F.:  Cushing's Syndrome in Children Associated with Adrenal Cortical Carcinoma: A Case Report with Review of the Literature , A. M. A. J. Dis. Child. 92: 297, 1956;.
2 +
Albright, F., and Forbes, A. P.: Personal Communication as quoted by Guin and Gilbert.1
3 +
Forsham, P. H., and Thorn, G. W.:  The Adrenals , in Textbook of Endocrinology , edited by R. H. Williams Ed. 2, Philadelphia, W. B. Saunders Company, 1955;, pp. 272-286.
4 +
Powell, L. W., Jr.; Newman, S., and Hooker, J. W.:  Cushing's Syndrome: Report of a Case in an Infant 12 Weeks Old , A. M. A. Am. J. Dis. Child. 90:417, 1955;.
5 +
Lightwood, R. C.:  Tumor of the Suprarenal Cortex in an Infant of 18 Weeks , Arch. Dis. Childhood 7:35, 1932;.
6 +
Talbot, N. B.; Sobel, E. H.; McArthur, J., and Crawford, J. D.: Functional Endocrinology from Birth Through Adolescence , Cambridge, Mass., Harvard University Press, 1952;, pp. 235-247.
7 +
Goldstein, H. M.:  Cushing's Syndrome Due to Tumor of the Adrenal Cortex: Report of a Case of an 11 Month Old Infant, with Apparent Operative Cure , Am. J. Dis. Child. 78:260, 1949;.
8 +
Farber, J. E.; Gustina, F. J., and Postoloff, A. V.:  Cushing's Syndrome in Children: Review of the Literature and Report of a Case , Am. J. Dis. Child. 65:593, 1943;.
9 +
Chute, A. L.; Robinson, G. C., and Donohue, W. L.:  Cushing's Syndrome in Children , J. Pediat. 34:20, 1949;.
10 +
Sobel, E. H.; Lee, C. M.; Esselborn, V. M., and Clark, L. C., Jr.:  Functioning Adrenal Tumors in Childhood: Consideration of Diagnosis, Surgical Approach, and Postoperative Management , A. M. A. Am. J. Dis. Child. 86:733, 1953;.
11 +
Marks, T. M.; Thomas, J. M., and Warkany, J.:  Adrenocortical Obesity in Children , Am. J. Dis. Child. 60:923, 1940;.
12 +
Forbes, A. P., and Albright, F.:  Comparison of 17-Ketosteroid Excretion in Cushing's Syndrome Associated with Adrenal Tumors and Adrenal Hyperplasia , J. Clin. Endocrinol. 11:926, 1951;.
13 +
Lindsay, A. E.; Migeon, C. J.; Nugent, C. A., and Brown, H.:  The Diagnostic Value of Plasma and Urinary 17-Hydroxycorticosteroid Determinations in Cushing's Syndrome , Am. J. Med. 20:15, 1956;.
14 +
Laidlaw, T. C.; Reddy, W. J.; Jenkins, D.; Haydar, N. A.; Renold, A. E., and Thorn, G. W.:  Advances in the Diagnosis of Altered States of Adrenocortical Function , New England J. Med. 253:746, 1955;.
15 +
Weinberg, T.:  Contralateral Atrophy Associated with Cortical Adrenal Neoplasm , New York J. Med. 41:884, 1941;.
16 +
Soffer, L. J.: Diseases of the Endocrine Glands , Ed. 2, Philadelphia, Lea & Febiger, 1956;, Ch. 11. Adrenocortical Hyperfunction, pp. 335-414.
17 +
Drekter, I. J.; Pearson, S.; Bartczak, E., and McGavack, T. H.:  A Rapid Method for the Determination of Total Urinary 17-Ketosteroids , J. Clin. Endocrinol. 7:795, 1947;.
18 +
Reddy, W. J.; Jenkins, D., and Thorn, G. W.:  Estimation of 17-Hydroxycorticoids in Urine , Metabolism 1:511, 1952;.

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References

1 +
Guin, G. H., and Gilbert, E. F.:  Cushing's Syndrome in Children Associated with Adrenal Cortical Carcinoma: A Case Report with Review of the Literature , A. M. A. J. Dis. Child. 92: 297, 1956;.
2 +
Albright, F., and Forbes, A. P.: Personal Communication as quoted by Guin and Gilbert.1
3 +
Forsham, P. H., and Thorn, G. W.:  The Adrenals , in Textbook of Endocrinology , edited by R. H. Williams Ed. 2, Philadelphia, W. B. Saunders Company, 1955;, pp. 272-286.
4 +
Powell, L. W., Jr.; Newman, S., and Hooker, J. W.:  Cushing's Syndrome: Report of a Case in an Infant 12 Weeks Old , A. M. A. Am. J. Dis. Child. 90:417, 1955;.
5 +
Lightwood, R. C.:  Tumor of the Suprarenal Cortex in an Infant of 18 Weeks , Arch. Dis. Childhood 7:35, 1932;.
6 +
Talbot, N. B.; Sobel, E. H.; McArthur, J., and Crawford, J. D.: Functional Endocrinology from Birth Through Adolescence , Cambridge, Mass., Harvard University Press, 1952;, pp. 235-247.
7 +
Goldstein, H. M.:  Cushing's Syndrome Due to Tumor of the Adrenal Cortex: Report of a Case of an 11 Month Old Infant, with Apparent Operative Cure , Am. J. Dis. Child. 78:260, 1949;.
8 +
Farber, J. E.; Gustina, F. J., and Postoloff, A. V.:  Cushing's Syndrome in Children: Review of the Literature and Report of a Case , Am. J. Dis. Child. 65:593, 1943;.
9 +
Chute, A. L.; Robinson, G. C., and Donohue, W. L.:  Cushing's Syndrome in Children , J. Pediat. 34:20, 1949;.
10 +
Sobel, E. H.; Lee, C. M.; Esselborn, V. M., and Clark, L. C., Jr.:  Functioning Adrenal Tumors in Childhood: Consideration of Diagnosis, Surgical Approach, and Postoperative Management , A. M. A. Am. J. Dis. Child. 86:733, 1953;.
11 +
Marks, T. M.; Thomas, J. M., and Warkany, J.:  Adrenocortical Obesity in Children , Am. J. Dis. Child. 60:923, 1940;.
12 +
Forbes, A. P., and Albright, F.:  Comparison of 17-Ketosteroid Excretion in Cushing's Syndrome Associated with Adrenal Tumors and Adrenal Hyperplasia , J. Clin. Endocrinol. 11:926, 1951;.
13 +
Lindsay, A. E.; Migeon, C. J.; Nugent, C. A., and Brown, H.:  The Diagnostic Value of Plasma and Urinary 17-Hydroxycorticosteroid Determinations in Cushing's Syndrome , Am. J. Med. 20:15, 1956;.
14 +
Laidlaw, T. C.; Reddy, W. J.; Jenkins, D.; Haydar, N. A.; Renold, A. E., and Thorn, G. W.:  Advances in the Diagnosis of Altered States of Adrenocortical Function , New England J. Med. 253:746, 1955;.
15 +
Weinberg, T.:  Contralateral Atrophy Associated with Cortical Adrenal Neoplasm , New York J. Med. 41:884, 1941;.
16 +
Soffer, L. J.: Diseases of the Endocrine Glands , Ed. 2, Philadelphia, Lea & Febiger, 1956;, Ch. 11. Adrenocortical Hyperfunction, pp. 335-414.
17 +
Drekter, I. J.; Pearson, S.; Bartczak, E., and McGavack, T. H.:  A Rapid Method for the Determination of Total Urinary 17-Ketosteroids , J. Clin. Endocrinol. 7:795, 1947;.
18 +
Reddy, W. J.; Jenkins, D., and Thorn, G. W.:  Estimation of 17-Hydroxycorticoids in Urine , Metabolism 1:511, 1952;.

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