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July 1957, Vol 94, No. 1 >
Article | July 1957

The Sweat Test in Cystic Fibrosis of the Pancreas FREE

C. L. J. VINK, Ph.D.
[+] Author Affiliations

Submitted for publication Dec. 1, 1956; accepted Jan. 24, 1957.


AMA Am J Dis Child. 1957;94(1):40-45. doi:10.1001/archpedi.1957.04030020042009.
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Introduction  In 1953 di Sant'Agnese et al.1,2 described a new diagnostic test for cystic fibrosis of the pancreas. This test was based on their discovery that the Na and Cl concentrations in sweat of patients with this disease is usually significantly higher than in normal persons and higher than in patients with a variety of other diseases. In the meanwhile other groups of investigators 3-5 came to the same conclusion.The object of this article is

  1. To examine whether a difference exists in the sweat-excretion rate at different places on the abdomen.

  2. To compare the concentrations of Na and Cl in the sweat at these places and to determine whether there are extreme variations in concentration which would affect the value of the sweat test.

  3. To compare our results of sweat analysis of patients with cystic fibrosis of the pancreas, of relatives of these patients, and

REFERENCES

1 +
di Sant'Agnese, P. A.; Darling, R. C.; Perera; G. A., and Shea, E.:  Abnormal Electrolyte Composition of Sweat in Cystic Fibrosis of the Pancreas: Clinical Significance and Relationship to the Disease , Pediatrics 12:549, 1953;.
2 +
di Sant'Agnese, P. A.:  Fibrocystic Disease of the Pancreas, a Generalized Disease of Exocrine Glands , J. A. M. A. 160:846, 1956;.
3 +
Shwachman, H.; Leubner, H., and Catzel, P.: Mucoviscidosis , in Advances in Pediatrics, Vol. 7, Edited by S. Z. Levine, Chicago, Year Book Publishers, Inc., 1955;.
4 +
Barbero, G. J.; Ih, C. K., and Mc Gravan, J.:  A Simplified Technique for the Sweat Test in the Diagnosis of Fibrocystic Disease of the Pancreas , Pediatrics 18:189, 1956;.
5 +
Mauer, A. M., and West, C. D.:  A Simple Method for Collection and Analysis of Sweat for Chloride , A.M.A. J. Dis. Child. 92:160, 1956;.
6 +
Jaartsveld, J. P.: Fibrosis van het pancreas, Thesis, Amsterdam, 1955.
7 +
Anfanger, H., and Heavenrich, R. M.:  Amino Acid Tolerance Tests in Children , Am. J. Dis. of Child. 77:425, 1949;.
8 +
Strengers, T., and Asberg, E. G. M. T.:  Een snelle microchloorbepaling , Nederl. tijdschr. geneesk. 97:2018, 1953;.
9 +
Locke, W.; Talbot, N. B.; Jones, H. S., and Worcester, J.:  Studies on the Combined Use of Measurements of Sweat Electrolyte Composition and Rate of Sweating as an Index of Adrenal Cortical Activity , J. Clin. Invest. 30:325, 1951;.
10 +
Shwachman, H.; Higgins, E., and Dooley, R. R.: Sweat Electrolytes, Read at the Annual Meeting of the American Academy of Pediatrics, Chicago, October, 1954.
11 +
Shwachman, H.; Pryles, C. V., and Gross, R. E.:  Meconium Ileus: A Clinical Study of 20 Surviving Patients , Am. J. Dis. Child. 91:223, 1956;.
12 +
di Sant'Agnese, P. A.:  Cystic Fibrosis of the Pancreas , Am. J. Med. 21:406, 1956;.
13 +
di Sant'Agnese, P. A.:  Fibrocystic Disease of the Pancreas with Normal or Partial Pancreatic Function: Current Views on Pathogenesis and Diagnosis , Pediatrics 15:683, 1955;.

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References

1 +
di Sant'Agnese, P. A.; Darling, R. C.; Perera; G. A., and Shea, E.:  Abnormal Electrolyte Composition of Sweat in Cystic Fibrosis of the Pancreas: Clinical Significance and Relationship to the Disease , Pediatrics 12:549, 1953;.
2 +
di Sant'Agnese, P. A.:  Fibrocystic Disease of the Pancreas, a Generalized Disease of Exocrine Glands , J. A. M. A. 160:846, 1956;.
3 +
Shwachman, H.; Leubner, H., and Catzel, P.: Mucoviscidosis , in Advances in Pediatrics, Vol. 7, Edited by S. Z. Levine, Chicago, Year Book Publishers, Inc., 1955;.
4 +
Barbero, G. J.; Ih, C. K., and Mc Gravan, J.:  A Simplified Technique for the Sweat Test in the Diagnosis of Fibrocystic Disease of the Pancreas , Pediatrics 18:189, 1956;.
5 +
Mauer, A. M., and West, C. D.:  A Simple Method for Collection and Analysis of Sweat for Chloride , A.M.A. J. Dis. Child. 92:160, 1956;.
6 +
Jaartsveld, J. P.: Fibrosis van het pancreas, Thesis, Amsterdam, 1955.
7 +
Anfanger, H., and Heavenrich, R. M.:  Amino Acid Tolerance Tests in Children , Am. J. Dis. of Child. 77:425, 1949;.
8 +
Strengers, T., and Asberg, E. G. M. T.:  Een snelle microchloorbepaling , Nederl. tijdschr. geneesk. 97:2018, 1953;.
9 +
Locke, W.; Talbot, N. B.; Jones, H. S., and Worcester, J.:  Studies on the Combined Use of Measurements of Sweat Electrolyte Composition and Rate of Sweating as an Index of Adrenal Cortical Activity , J. Clin. Invest. 30:325, 1951;.
10 +
Shwachman, H.; Higgins, E., and Dooley, R. R.: Sweat Electrolytes, Read at the Annual Meeting of the American Academy of Pediatrics, Chicago, October, 1954.
11 +
Shwachman, H.; Pryles, C. V., and Gross, R. E.:  Meconium Ileus: A Clinical Study of 20 Surviving Patients , Am. J. Dis. Child. 91:223, 1956;.
12 +
di Sant'Agnese, P. A.:  Cystic Fibrosis of the Pancreas , Am. J. Med. 21:406, 1956;.
13 +
di Sant'Agnese, P. A.:  Fibrocystic Disease of the Pancreas with Normal or Partial Pancreatic Function: Current Views on Pathogenesis and Diagnosis , Pediatrics 15:683, 1955;.

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