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II. Laboratory Findings in One Hundred Six Instances

T. S. DANOWSKI, M.D.; F. A. WEIGAND, M.D.; LAWRENCE GREENMAN, M.D.; S. GAILANI, M.D.; W. V. GREENBERG, M.D.; F. M. MATEER, M.D.
AMA Am J Dis Child. 1957;93(6):604-614. doi:10.1001/archpedi.1957.02060040606002.
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In a previous report we have described the clinical results and the changes in proteinuria in a total of 106 instances of nephrotic syndrome in children treated, usually for 28 days, with corticotropin (ACTH),* 100 to 200 units per day, a very low-sodium high-potassium diet, and penicillin.1 The alterations in the formed elements of the blood, in serum and blood solutes, and in urinary reducing substances and 17-ketosteroids prior to, during, and following therapy are herein presented.

Materials and Methods  Erythrocyte, leukocyte, and differential blood cell counts; the hemoglobin content; the levels of whole-blood nonprotein nitrogen and sugar; the presence of reducing substances in the urine (Benedict's test); the concentrations of carbon dioxide, chloride, sodium, potassium, total protein, albumin, globulin, calcium, inorganic phosphorus, and cholesterol in serum, and the 24-hour excretion rates of urinary 17-ketosteroids were measured at approximately weekly intervals before, during, and after therapy by methods in

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