May 1957, Vol 93, No. 5 >

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Article | May 1957

Development of Sulfadiazine Resistance During an Outbreak of Shigellosis Due to Shigella Sonnei Form I

FREDERICK H. WENTWORTH, M.D.; BERTTINA WENTWORTH, M.T. (A.S.C.P.)

AMA Am J Dis Child. 1957;93(5):551-554. doi:10.1001/archpedi.1957.02060040553009.

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The efficacy of sulfadiazine in the treatment of Shigella infections, where the organism is sensitive to sulfonamides, has been well established,^1-3 and because of its relatively low toxicity and general availability it has appeared to be the drug of choice in shigellosis therapy.³ However, the problem of the development of sulfonamideresistant strains was recognized in these early reports and independently reported by others.⁴ In recent years several investigators have reported outbreaks in which resistant strains have either predominated or have been the only strains isolated.^5-7 Hardy's report,³ however, is the only one which has come to our attention which demonstrated the development of resistant strains during an outbreak, with the subsequent spread of sulfonamide-resistant infections in the study population.

An unusual opportunity to study the development of sulfadiazine resistance was afforded us by an outbreak of shigellosis due to Shigella sonnei Form I in an

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WENTWORTH FH, WENTWORTH B. Development of Sulfadiazine Resistance During an Outbreak of Shigellosis Due to Shigella Sonnei Form I. AMA Am J Dis Child. 1957;93(5):551-554. doi:10.1001/archpedi.1957.02060040553009.

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Development of Sulfadiazine Resistance During an Outbreak of Shigellosis Due to Shigella Sonnei Form I

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