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Vitamin-D-Resistant Rickets

AMA Am J Dis Child. 1957;93(4):385-390. doi:10.1001/archpedi.1957.02060040387005.
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The familial character of vitamin-D-resistant rickets has been mentioned in the past, yet the exact mode of its inheritance has been neglected. There have been postulations of the dominant character of the trait, but this has been surmised from a few isolated cases which have not received sufficient attention with regard to the entire family history.

The disease was first described by Albright, Butler, and Bloomberg1 and the familial tendency was soon recognized by Gill2 and Christensen.3 Since Pederson and McCarroll4 found this disease to be a leading cause of dwarfism in their clinic, the determination of the mechanism of inheritance is important from the standpoint of family counseling.

The purpose of this paper is to report an additional case of vitamin-D-resistant rickets in a child whose family history is rather striking in that five generations of her family show members to be affected with this


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