0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

The Pathological Changes in the Liver in Cystic Fibrosis of the Pancreas

JOHN M. CRAIG, M.D.; HESKELL HADDAD, M.D.; HARRY SHWACHMAN, M.D.
AMA Am J Dis Child. 1957;93(4):357-369. doi:10.1001/archpedi.1957.02060040359002.
Text Size: A A A
Published online

Once cystic fibrosis of the pancreas had been recognized as a clinical and pathological entity, histological alteration of the liver was found to be a common feature of the total process1-3 with qualitative and quantitative differences. The basic liver lesions described have included liver-cell atrophy, fatty metamorphosis, periportal fibrosis, and proliferation of the bile ducts, often distended by obstructing bile plugs.1-7 In certain more advanced cases, a focal biliary cirrhosis was found, and this has been considered by most to be due to the focal obstructive lesions resulting from the altered and inspissated bile-containing mucus plugs in the dilated terminal radicles.1-3,5,7-13*

This report is a review of the clinical records and postmortem material of 198 autopsied cases of cystic fibrosis of the pancreas. An attempt is made to define the liver changes, to indicate the pathogenesis, and to relate their changes noted to the total clinical picture

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();