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Unilateral Multicystic Renal Disease of the Newborn

AMA Am J Dis Child. 1956;92(6):576-580. doi:10.1001/archpedi.1956.02060030570005.
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Unilateral multicystic disease is rare, but its recognition is important because surgical treatment is so satisfactory even in infants. It must be differentiated from the other forms of renal cystic disease, that is, bilateral polycystic disease or solitary cysts of the kidney.*

Review of the Literature  Bugbee and Wollstein6 studied the urinary tract of 4903 infants at necropsy and found a total of only four cases of unilateral cystic renal disease, an incidence of 0.1%. In the same study 11 bilateral cystic kidneys were found, 0.2%.The present knowledge of the pathogenesis of these disorders is scant and theoretical. It is known, however, that the ureteral bud (which is derived from the Wolfian duct) as it ascends from the pelvis to form the collecting system of the permanent kidney must unite with the nephrons of the metanephrons. The most widely accepted theory concerning the origin of the polycystic and


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