Following the use of the administration of iodized oils as a test for fat absorption, Silverman and Shirkey1 introduced a simple modification in which a qualitative test for iodine was performed on varying dilutions of urine collected 12-18 hours following oral ingestion of iodized oil (Lipiodol). They claimed that a positive test for iodine after the ingestion of iodized oil in a dilution of 1 in 4 or greater probably excludes fibrocystic disease of the pancreas as a diagnosis. Our experience with this test was most disappointing, negative results on undiluted urine being often found even with urine of normal controls.We therefore tried the effect of determining the urine iodine quantitatively while preserving the simplicity of the Silverman-Shirkey technique.
Iodized oil was administered to patients in the Children's Hospital, Winnipeg, in the manner described by Silverman and Shirkey. Samples of urine were collected before and