0
July 1956, Vol 92, No. 1 >
Article | July 1956

The Treatment of Tuberculous Meningitis Without Injections FREE

W. P. SWEETNAM, M.D., M.R.C.P., D.P.H., D.C.H.; C. G. W. SYKES, M.B., D.R.C.O.G., D.C.H.
[+] Author Affiliations

Submitted for publication March 22, 1956.


AMA Am J Dis Child. 1956;92(1):2-4. doi:10.1001/archpedi.1956.02060030004002.
Text Size: A A A
Published online
Article
References
Comments

The treatment of tuberculous meningitis has undergone a progressive review following the introduction of streptomycin and later of aminosalicylic acid (PAS) and isoniazid. Streptomycin has two main disadvantages—the need for prolonged injections and the occasional toxicity of the antibiotic. Oral isoniazid has been shown to produce adequate bacteriostatic levels in the C. S. F. (Fletcher, 1953) and to be virtually nontoxic (Medical Research Council, 1953).

Smellie (1954) has drawn attention to the pain and suffering caused to children by prolonged courses of intrathecal and intramuscular injections, and suggests, from his own experience, that intrathecal treatment can be dispensed with. Morin (1952) obtained promising results in five patients with the use of isoniazid alone, a short course of intrathecal treatment being given. Applebaum and Anderson (1954) report 7 recoveries in 10 cases treated with isoniazid or iproniazid; in 3 cases the initial therapy was administered intramuscularly. Sweetnam and Murphy (1952, 1954)

REFERENCES

1 +
Applebaum, E., and Anderson, T. A.: J. A. M. A. 156:673, 1954;.
2 +
Fletcher, A. P.: Lancet 2:694, 1953;.
3 +
Streptomycin in Tuberculosis Trials Committee,  Medical Research Council , Lancet 254:582, 1948;.
4 +
 Second Report to the Medical Research Council by Their Tuberculosis Chemotherapy Trials Committee , Brit. Med. J. 1:521, 1953;.
5 +
Morin, J.: Schweitz. Ztschr. Tuberk. 9:243, 1952;;
6 +
abstracted, Am. Rev. Tuberc. 67:16, 1953;.
7 +
Ratner, B.; Greenberg, E., and Burke, J. C.: Pediatrics 11:82, 1953;.
8 +
Smellie, J. M.: Lancet 267:1091, 1954;.
9 +
Spies, H. W.; Lepper, M. H.; Blatt, N. H., and Dowling, H. F.: Am. Rev. Tuberc. 69:192, 1954;.
10 +
Sweetnam, W. P., and Murphy, E. F.: Lancet 2:691, 1953;.
11 +
Sweetnam, W. P., and Murphy, E. F.: Arch. Dis. Childhood 29:366, 1954;.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Applebaum, E., and Anderson, T. A.: J. A. M. A. 156:673, 1954;.
2 +
Fletcher, A. P.: Lancet 2:694, 1953;.
3 +
Streptomycin in Tuberculosis Trials Committee,  Medical Research Council , Lancet 254:582, 1948;.
4 +
 Second Report to the Medical Research Council by Their Tuberculosis Chemotherapy Trials Committee , Brit. Med. J. 1:521, 1953;.
5 +
Morin, J.: Schweitz. Ztschr. Tuberk. 9:243, 1952;;
6 +
abstracted, Am. Rev. Tuberc. 67:16, 1953;.
7 +
Ratner, B.; Greenberg, E., and Burke, J. C.: Pediatrics 11:82, 1953;.
8 +
Smellie, J. M.: Lancet 267:1091, 1954;.
9 +
Spies, H. W.; Lepper, M. H.; Blatt, N. H., and Dowling, H. F.: Am. Rev. Tuberc. 69:192, 1954;.
10 +
Sweetnam, W. P., and Murphy, E. F.: Lancet 2:691, 1953;.
11 +
Sweetnam, W. P., and Murphy, E. F.: Arch. Dis. Childhood 29:366, 1954;.

Correspondence

Submit a Letter
CME
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Clear Answers | Save For Later
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Comment

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

© 2013 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems