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June 1956, Vol 91, No. 6 >
Article | June 1956

The Effect of Pancreatin on Fat Digestion in an Infant FREE

B. B. KUMAR, M.B., B.S., D.C.H.; G. E. GIBBS, Ph.D., M.D.
[+] Author Affiliations

Submitted for publication Jan. 5, 1956.

This study was aided by the Gary Ralston Memorial Fund and by a grant from the A. M. A. Council on Pharmacy and Chemistry.

References 4 and 5.


AMA Am J Dis Child. 1956;91(6):606-607. doi:10.1001/archpedi.1956.02060020608015.
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The effectiveness of pancreatin in treatment of pancreatic deficiency has long been a subject of controversy. Recently reported balance studies by Ross 1 and by Harris and co-workers2 on a total of 23 infants and children indicate that pancreatin is effective in improving fat utilization. Vitamin A absorption studies have also tended to confirm this lipolytic effectiveness of pancreatin.3

Additional data regarding the effect of pancreatin on fat digestion are provided by the present study, in which 10 paired balance periods were observed in a single infant with pancreatic exocrine deficiency. The age of the infant was 2 months at the beginning of the experiment. He weighed 4500 gm. at that time and increased to 5400 gm. by the end of the study, at age of 4 months. No family history of pancreatic exocrine disease was known. Pancreatic deficiency was proved by duodenal drainage with use of

REFERENCES

1 +
Ross, C. A. C.:  Fat Absorption Studies in the Diagnosis and Treatment in Pancreatic Fibrosis , Arch. Dis. Childhood 30:316, 1955;.
2 +
Harris, R.; Norman, A. P., and Payne, W. W.:  The Effect of Pancreatin Therapy on Fat Absorption and Nitrogen Retention in Children with Fibrocystic Disease of the Pancreas , Arch. Dis. Childhood 30:424, 1955;.
3 +
Gibbs, G. E.:  Effect of Pancreatin in Plasma Vitamin A Curves in the Celiac Syndrome , Pediat. 6:593, 1950;.
4 +
Gibbs, G. E.:  Secretin Tests with Bilumen Gastroduodenal Drainage in Infants and Children , Pediatrics 5:941, 1950;.
5 +
Gibbs, G. E.; Bostick, W. L., and Smith, P. M.:  Incomplete Pancreatic Deficiency in Cystic Fibrosis of the Pancreas , J. Pediat. 37:320, 1950;.
6 +
Bessman, S. P.; McGrady, K., and Ivins, I.:  Saliva Chlorides in Fibrocystic Disease, Scientific Exhibit , American Academy of Pediatrics , Chicago, (Oct.) 1-6, 1955;.
7 +
Shwachman, H., and Leubner, H.:  Mucoviscidosis , in Advances in Pediatrics edited by S. Z. Levine , Chicago, Year Book Publishers, Inc., 1955;, Vol. 2, p. 289.
8 +
van de Kamer, J. H.; ten Bokkel Huinink, H., and Weyers, H. A.:  Rapid Method for the Determination of Fat in Feces , J. Biol. Chem. 177: 347, 1949;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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References

1 +
Ross, C. A. C.:  Fat Absorption Studies in the Diagnosis and Treatment in Pancreatic Fibrosis , Arch. Dis. Childhood 30:316, 1955;.
2 +
Harris, R.; Norman, A. P., and Payne, W. W.:  The Effect of Pancreatin Therapy on Fat Absorption and Nitrogen Retention in Children with Fibrocystic Disease of the Pancreas , Arch. Dis. Childhood 30:424, 1955;.
3 +
Gibbs, G. E.:  Effect of Pancreatin in Plasma Vitamin A Curves in the Celiac Syndrome , Pediat. 6:593, 1950;.
4 +
Gibbs, G. E.:  Secretin Tests with Bilumen Gastroduodenal Drainage in Infants and Children , Pediatrics 5:941, 1950;.
5 +
Gibbs, G. E.; Bostick, W. L., and Smith, P. M.:  Incomplete Pancreatic Deficiency in Cystic Fibrosis of the Pancreas , J. Pediat. 37:320, 1950;.
6 +
Bessman, S. P.; McGrady, K., and Ivins, I.:  Saliva Chlorides in Fibrocystic Disease, Scientific Exhibit , American Academy of Pediatrics , Chicago, (Oct.) 1-6, 1955;.
7 +
Shwachman, H., and Leubner, H.:  Mucoviscidosis , in Advances in Pediatrics edited by S. Z. Levine , Chicago, Year Book Publishers, Inc., 1955;, Vol. 2, p. 289.
8 +
van de Kamer, J. H.; ten Bokkel Huinink, H., and Weyers, H. A.:  Rapid Method for the Determination of Fat in Feces , J. Biol. Chem. 177: 347, 1949;.

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