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May 1956, Vol 91, No. 5 >
Article | May 1956

INVOLVEMENT OF THE CENTRAL NERVOUS SYSTEM IN INFECTIOUS MONONUCLEOSIS IN CHILDHOOD FREE

HENRY K. SILVER, M.D.; WILLIAM O. ROBERTSON, M.D.; JOE D. WRAY, M.D.; FRANK L. GRUSKAY, M.D.
[+] Author Affiliations

Received for publication Oct. 31, 1955.


AMA Am J Dis Child. 1956;91(5):490-494. doi:10.1001/archpedi.1956.02060020492012.
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INFECTIOUS mononucleosis with manifestations involving the central nervous system is apparently uncommon in childhood. Although over 100 cases with neurologic signs have been reported in all age groups, only 11 of these were in children. Specifically, convulsions have occurred in a total of 13 cases, but in only 4 were the patients less than 16 years old. The purpose of this paper is to report a child with infectious mononucleosis whose presenting sign was a grand mal seizure and to review some of the findings gathered from the literature.

REPORT OF CASE  A 9-year-old white boy was admitted to the pediatric service of the Grace-New Haven Community Hospital on Nov. 8, 1954, for evaluation of a grand mal seizure. The youngest of 10 normal children, he had always been in good health, somehow escaping the usual contagious childhood diseases. Two weeks prior to admission, he had had a mild upper

REFERENCES

1 +
Bernstein, T. C., and Wolff, H. G.:  Involvement of Nervous System in Infectious Mononucleosis , Ann. Int. Med. 33:1120, 1950;.
2 +
Walsh, F. C.; Pozer, C. M., and Carter, S.:  Infectious Mononucleosis Encephalitis , Pediatrics 13:536, 1954;.
3 +
Karpinski, F. E., Jr.:  Neurologic Manifestations of Infectious Mononucleosis in Childhood , Pediatrics 10:265, 1952;.
4 +
Bonynge, T. W., and Von Hagen, K. O.:  Severe Optic Neuritis in Infectious Mononucleosis: Report of Case , J. A. M. A. 148:933, 1952;.
5 +
Geliebter, S.:  Acute Infectious Mononucleosis Complicated by Encephalomyelitis: Report of Case , Lancet 2:753, 1946;.
6 +
Klovstad, O.:  Guillain-Barré Syndrome in Infectious Mononucleosis , Acta med. scandinav. 138:67, 1950;.
7 +
Shechter, F. R.; Lipsius, E. I., and Rasansky, H. N.:  Retrobulbar Neuritis: Complication of Infectious Mononucleosis , A. M. A. Am. J. Dis. Child. 89:58, 1955;.
8 +
Silberstein, J. K.; Bernstein, T. C., and Stern, T.:  Demonstration of Heterophile Antibodies in Cerebrospinal Fluid from Patients with Infectious Mononucleosis , J. Lab. & Clin. Med. 33:1204, 1948;.
9 +
Custer, R. P., and Smith, E. B.:  Pathology of Infectious Mononucleosis , Blood 3:830, 1948;.
10 +
Sucher, A., and Schwarz, E.:  Lymphatische Reaktion und Encephalomeningitis , Wien. klin. Wchnschr. 49:1417, 1936;.
11 +
Schmidt, V., and Nyfeldt, A.:  Infectious Mononucleosis und Meningoencephalitis , Ugesk. læger 100:336, 1938;.
12 +
Coogan, T. J.; Martinson, D. L., and Mathews, W. H.:  Neurological Symptoms of Infectious Mononucleosis , Illinois M. J. 87:293, 1945;.
13 +
Landes, R.; Reich, J. P., and Perlow, S.:  Central Nervous System Manifestations of Infectious Mononucleosis: Report of Case , J. A. M. A. 116:2482, 1941;.
14 +
Slade, J. deR.:  Involvement of Central Nervous System in Infectious Mononucleosis: Report of 2 Cases , New England J. Med. 234:753, 1946;.
15 +
Schneider, T., and Michelson, D. A.:  Central System Manifestations of Glandular Fever . South African M. J. 21:57, 1947;.

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References

1 +
Bernstein, T. C., and Wolff, H. G.:  Involvement of Nervous System in Infectious Mononucleosis , Ann. Int. Med. 33:1120, 1950;.
2 +
Walsh, F. C.; Pozer, C. M., and Carter, S.:  Infectious Mononucleosis Encephalitis , Pediatrics 13:536, 1954;.
3 +
Karpinski, F. E., Jr.:  Neurologic Manifestations of Infectious Mononucleosis in Childhood , Pediatrics 10:265, 1952;.
4 +
Bonynge, T. W., and Von Hagen, K. O.:  Severe Optic Neuritis in Infectious Mononucleosis: Report of Case , J. A. M. A. 148:933, 1952;.
5 +
Geliebter, S.:  Acute Infectious Mononucleosis Complicated by Encephalomyelitis: Report of Case , Lancet 2:753, 1946;.
6 +
Klovstad, O.:  Guillain-Barré Syndrome in Infectious Mononucleosis , Acta med. scandinav. 138:67, 1950;.
7 +
Shechter, F. R.; Lipsius, E. I., and Rasansky, H. N.:  Retrobulbar Neuritis: Complication of Infectious Mononucleosis , A. M. A. Am. J. Dis. Child. 89:58, 1955;.
8 +
Silberstein, J. K.; Bernstein, T. C., and Stern, T.:  Demonstration of Heterophile Antibodies in Cerebrospinal Fluid from Patients with Infectious Mononucleosis , J. Lab. & Clin. Med. 33:1204, 1948;.
9 +
Custer, R. P., and Smith, E. B.:  Pathology of Infectious Mononucleosis , Blood 3:830, 1948;.
10 +
Sucher, A., and Schwarz, E.:  Lymphatische Reaktion und Encephalomeningitis , Wien. klin. Wchnschr. 49:1417, 1936;.
11 +
Schmidt, V., and Nyfeldt, A.:  Infectious Mononucleosis und Meningoencephalitis , Ugesk. læger 100:336, 1938;.
12 +
Coogan, T. J.; Martinson, D. L., and Mathews, W. H.:  Neurological Symptoms of Infectious Mononucleosis , Illinois M. J. 87:293, 1945;.
13 +
Landes, R.; Reich, J. P., and Perlow, S.:  Central Nervous System Manifestations of Infectious Mononucleosis: Report of Case , J. A. M. A. 116:2482, 1941;.
14 +
Slade, J. deR.:  Involvement of Central Nervous System in Infectious Mononucleosis: Report of 2 Cases , New England J. Med. 234:753, 1946;.
15 +
Schneider, T., and Michelson, D. A.:  Central System Manifestations of Glandular Fever . South African M. J. 21:57, 1947;.

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