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May 1956, Vol 91, No. 5 >
Article | May 1956

VIII. Trials of Protein Hydrolysate, Vitamin Supplements, and Physical Therapy FREE

J. S. DONALDSON, M.D.; M. J. WRATNEY, B.S., M.Ed.; A. PASCASSIO; F. A. WEIGAND, M.D.; T. S. DANOWSKI, M.D.
[+] Author Affiliations

Submitted for publication Aug. 31, 1955.

Supported by grants-in-aid from the Muscular Dystrophy Associations of America, Incorporated, and the American Cancer Society.

References 1 and 2.

References 3-7.

One heaping teaspoon of Walker protein hydrolysate t. i. d. and 1 capsule of Rubrafolin b. i. d. According to the manufacturer, Walker protein hydrolysate contains the amino acids present in 16 gm. of an enzymatic digest of casein and the following: vitamin A, 5000 U. S. P. units; vitamin D, 500 U. S. P. units; thiamine HC1, 10 mg.; riboflavin, 6 mg.; pyridoxine HC1, 1 mg.; calcium pentothenate, 1 mg.; malinamide, 50 mg.; ascorbic acid, 100 mg.; iron peptonate, 0.1 gm.; and tribasic calcium phosphate, 1.0 gm. Each Squibb Rubrafolin capsule contains 257 of vitamin B12 and 1.67 mg. of folic acid. Walker Laboratories, Inc., and E. R. Squibb & Sons provided generous supplies of hydrolysate and Rubrafolin, respectively.


AMA Am J Dis Child. 1956;91(5):449-453. doi:10.1001/archpedi.1956.02060020451005.
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Comments

It has recently been reported that the ingestion of a protein hydrolysate together with a vitamin preparation produces distinct clinical improvement in muscular dystrophy.* A group of children believed to have this disease have therefore been placed on such a regimen. The results have been compared with those obtained with physical therapy alone as well as with the spontaneous changes which occur without hydrolysate and without physical therapy.

MATERIAL AND METHODS  Twenty-nine children afflicted with muscular dystrophy, 2 to 15 years of age, have been seen at intervals by a physical therapist, an orthopedist, and a physician. In all of these patients the diagnosis seems justified by virtue of the findings on physical examination and on biopsy of muscle sections. The details of these observations together with the results of certain biochemical studies of body fluids have been presented earlier.†Serial measurements of muscle strength have been made in the

REFERENCES

1 +
Van Meter, J. R.:  Progressive Muscular Dystrophy: A Preliminary Report on Treatment with Amino Acids, Folic Acid and Vitamins , California Med . 79:297-299 ( (Oct.) ) 1953;.
2 +
Davies, L.: New Method Aids Muscle Dystrophy , New York Times, p. 50, ( (Oct. 15) ) 1953;.
3 +
Fetterman, G. H.; Wratney, M. J.; Donaldson, J. S., and Danowski, T. S.:  Muscular Dystrophy: I. History, Clinical Status, Muscle Strength, and Biopsy Findings , A. M. A. J. Dis. Child. 91:326-338 ( (April) ) 1956;.
4 +
Girdany, B., and Danowski, T. S.:  Muscular Dystrophy: II. Radiologic Findings in Relation to Severity of Disease , A. M. A. J. Dis. Child. 91:339-345 ( (April) ) 1956;.
5 +
Danowski, T. S.; Wirth, P. M.; Leinberger, M. H.; Randall, L. A., and Peters, J. H.:  Muscular Dystrophy: III. Serum and Blood Solutes and Other Laboratory Indices , A. M. A. J. Dis. Child. 91:346-355 ( (April) ) 1956;.
6 +
Danowski, T. S.; Bastiani, R. M.; McWilliams, F. D.; Mateer, F. M., and Greenman, L.:  Muscular Dystrophy: IV. Endocrine Studies , A. M. A. J. Dis. Child. 91:356-364 ( (April) ) 1956;.
7 +
Danowski, T. S.; Greenman, L.; Mateer, F. M.; Wratney, M. J., and Donaldson, J. S.:  Muscular Dystrophy: VII. Trials of a Pituitary Growth Factor , A. M. A. J. Dis. Child. , this issue, p. 442.
8 +
Danowski, T. S.; Greenman, L.; Mateer, F. M.; Parsons, W. B.; Weigand, F. A.; Mermelstein, H., and Peters, J. H.:  Carboxylic Cation Exchange Resin Effects in Dogs , J. Clin. Invest. 30:984-994 ( (Sept.) ) 1951;.
9 +
Ziegler, D. K., von Storch, T. J. C.:  Psychology and Psychiatry , J. A. M. A. 157:466-467 ( (Jan. 29) ) 1955;.
10 +
White, J. E., and Schwartz, T. B.:  Lean Body Mass Determinations as an Aid in the Evaluation of Progressive Muscular Dystrophy , Clin. Res. Proc. 3:76-77 ( (Feb.) ) 1955;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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References

1 +
Van Meter, J. R.:  Progressive Muscular Dystrophy: A Preliminary Report on Treatment with Amino Acids, Folic Acid and Vitamins , California Med . 79:297-299 ( (Oct.) ) 1953;.
2 +
Davies, L.: New Method Aids Muscle Dystrophy , New York Times, p. 50, ( (Oct. 15) ) 1953;.
3 +
Fetterman, G. H.; Wratney, M. J.; Donaldson, J. S., and Danowski, T. S.:  Muscular Dystrophy: I. History, Clinical Status, Muscle Strength, and Biopsy Findings , A. M. A. J. Dis. Child. 91:326-338 ( (April) ) 1956;.
4 +
Girdany, B., and Danowski, T. S.:  Muscular Dystrophy: II. Radiologic Findings in Relation to Severity of Disease , A. M. A. J. Dis. Child. 91:339-345 ( (April) ) 1956;.
5 +
Danowski, T. S.; Wirth, P. M.; Leinberger, M. H.; Randall, L. A., and Peters, J. H.:  Muscular Dystrophy: III. Serum and Blood Solutes and Other Laboratory Indices , A. M. A. J. Dis. Child. 91:346-355 ( (April) ) 1956;.
6 +
Danowski, T. S.; Bastiani, R. M.; McWilliams, F. D.; Mateer, F. M., and Greenman, L.:  Muscular Dystrophy: IV. Endocrine Studies , A. M. A. J. Dis. Child. 91:356-364 ( (April) ) 1956;.
7 +
Danowski, T. S.; Greenman, L.; Mateer, F. M.; Wratney, M. J., and Donaldson, J. S.:  Muscular Dystrophy: VII. Trials of a Pituitary Growth Factor , A. M. A. J. Dis. Child. , this issue, p. 442.
8 +
Danowski, T. S.; Greenman, L.; Mateer, F. M.; Parsons, W. B.; Weigand, F. A.; Mermelstein, H., and Peters, J. H.:  Carboxylic Cation Exchange Resin Effects in Dogs , J. Clin. Invest. 30:984-994 ( (Sept.) ) 1951;.
9 +
Ziegler, D. K., von Storch, T. J. C.:  Psychology and Psychiatry , J. A. M. A. 157:466-467 ( (Jan. 29) ) 1955;.
10 +
White, J. E., and Schwartz, T. B.:  Lean Body Mass Determinations as an Aid in the Evaluation of Progressive Muscular Dystrophy , Clin. Res. Proc. 3:76-77 ( (Feb.) ) 1955;.

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