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VII. Trials of a Pituitary Growth Factor

T. S. DANOWSKI, M.D.; L. GREENMAN, M.D.; F. M. MATEER, M.D.; M. J. WRATNEY, B.S., M.Ed.; J. S. DONALDSON, M.D.
AMA Am J Dis Child. 1956;91(5):442-448. doi:10.1001/archpedi.1956.02060020444004.
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The demonstrations that pituitary growth hormone increased muscle and organ size and induced the retention of nitrogen and of electrolytes * prompted trials of this factor in muscular dystrophy when a "nondiabetogenic" preparation became available.

MATERIAL AND METHODS  Four children, 4 to 7 years of age, believed to have muscular dystrophy on the basis of clinical findings, biopsy of muscles, and laboratory studies, which have been described in greater detail in earlier publications,† received a preparation of pituitary growth factor for six to eight months at a daily dosage level of 3.0 mg. I. M. per kilogram of body weight. This material was prepared in accordance with the procedure of Raben and Westermeyer20 and found to restore growth in immature hypophysectomized mice.‡ The following observations were made in each of the four children:

  • Muscle strength was evaluated by the physical therapist prior to, during, and after the course of

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