Non-endocrine deviations from the normal pattern of osseous development were described in a previous study.1 Dwarfism and retarded skeletal maturation were reported in six boys, two of whom had heart murmurs and one bilateral "pseudoepiphyses."
The purpose of this communication is to report the observations in nine cases of an analogous linkage of dwarfism, retarded osseous maturation, a congenital heart murmur, and sexual infantilism in the three children who have reached the age of pubescence.
REPORT OF CASES
The important features of the cases are presented in the Table. The history of one case is reported in detail as a representative example of the entire group.Case 4.—A white boy who was first admitted to the hospital on March 24, 1951, at the age of 10 years, because of an undescended testicle and the question of adiposogenital dystrophy. He was an only child. Birth had occurred at term by