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Treatment of Streptococcal Carrier State in a Rural School

THOMAS B. HILL, M.D.
AMA Am J Dis Child. 1955;90(3):280-282. doi:10.1001/archpedi.1955.04030010282006.
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The successful use of oral penicillin to interrupt hemolytic streptococcal epidemics in large groups of armed forces is well established.1 This study is an attempt to apply the principles of group antibiotic therapy to prevent recurrent hemolytic Streptococcus infections in rural areas.

PROBLEM  For a two-year period, members of eight families had repeated upper-respiratory infections from which pharyngeal or tonsillar cultures were positive for a hemolytic Streptococcus (grouping and typing were not done). Penicillin therapy in the form of 200,000 units of an oral buffered penicillin three times a day for a period of 7 to 10 days or later 1,200,000 units of benzathine penicillin G (Bicillin) intramuscularly would give clinical cure of these infections, but the repeated recurrences made it evident that either a bacteriological cure was not obtained or reinfection was taking place. Cultures of other members of the family were usually negative, but even when

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