Thrombocytopenia associated with giant hemangioma in the infant produces a disorder featured by hemorrhagic tendency and the occurrence of bleeding into the hemangioma site. Hemorrhagic manifestations in these patients are frequently severe enough to threaten life, and infants have died of this disease. Weissman and Tagnon1 recently pointed out that enough cases of thrombocytopenia occurring in conjunction with large hemangiomas have been reported to justify considering the simultaneous occurrence of these disorders in the infant as a clinical syndrome. In spite of the established clinical association, the biologic relationship between the thrombopenia and hemangioma remains obscure, and some authors still consider the simultaneous occurrence of these disorders to be coincidental.
It is the purpose of this paper to summarize reported experience with cases of thrombocytopenia and hemangioma and to report three additional cases of our own. A review of the available literature indicates that a relationship between the hemangioma