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Hemodialysis of the Uremic Child FREE

F. M. MATEER, M.D.; L. GREENMAN, M.D.; T. S. DANOWSKI, M.D.
[+] Author Affiliations

Aided by a grant from the American Heart Association and the Committee on Research of the Council on Pharmacy and Chemistry of the American Medical Association.

References 1-3.

References 4-8.

References 9-13.

References 16-18.

References 20-22.


AMA Am J Dis Child. 1955;89(6):645-655. doi:10.1001/archpedi.1955.02050110785001.
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Vividialysis has proved itself useful in adults with renal disorders in which the fluid disturbances of uremia threaten life before reparative processes can restore kidney function. Two methods of dialysis have been employed: (1) lavage of a membrane within the body, either the peritoneum or an isolated loop of bowel, by dialyzing fluid,* and (2) extracorporeal hemodialysis in an artificial kidney using cellophane to separate the patient's blood from the lavage fluid.† Although the number of such dialyses performed in adult subjects can now be counted in hundreds,‡ the use of either method in therapy of children with far-advanced renal failure has been relatively infrequent. Peritoneal lavage in three uremic children was described by Swan, in 1949.14 However, due to various difficulties reported, such as occlusion of the siphon apparatus, loss of body protein, inability to regulate transfers of water and of electrolytes, and the danger of infection, we

REFERENCES

Rhoads, J. E.:  Peritoneal Lavage in Treatment of Renal Insufficiency , Acad. M. Sc. 196:642-647 ( (Nov.) ) 1938;.
Odel, H. M.; Ferris, D. 0., and Power, M. H.:  Peritoneal Lavage as Effective Means of Extrarenai Excretion: Clinical Appraisal , Am. J. Med. 9:63-77 ( (July) ) 1950;.
Muirhead, E. E. ; Small, A. B. ; Haley, A. E., and Hill, J. M.:  Peritoneal Irrigation for Acute Renal Damage Following Incompatible Blood Transfusion: Discussion Based on 3 Cases , J. Lab. & Clin. Med. 32:988-1001 ( (Aug.) ) 1947;.
Abel, J. J. ; Rowntree, L. C, and Turner, B. B.:  On the Removal of Diffusible Substances from the Circulating Blood of Living Animals by Dialysis , J. Pharmacol. & Exper. Therap. 5:275-316 ( (Jan.) ) 1913-1914;.
Necheles, H.:  Über dialysieren des stomenden blutes and lebenden , Klin. Wchnschr. 2:1257 ( (July 2) ) 1923;.
Darmady, E. M.:  Dialysis of Blood for Treatment of Uremia , Proc. Roy. Soc. Med. 41:418-419 ( (Jan. 22) ) 1928;.
Kolff, W. J., and Berk, H. T. J.:  Artificial Kidney: Dialyser with Great Area , Acta. med. scandinav. 117:121-134, 1944;.
Alwall, N.:  On Artificial Kidney: XI. Some Supplementary Constructional Details of Dialyser Intended for Rabbit and Homo , Acta. med. scandinav. (Supp. 229) , pp. 20-21, 1949;.
Kolff, W. J.: New Ways of Treating Uraemia: Artificial Kidney, Peritoneal Lavage, Intestinal Lavage , London, J. & A. Churchill, Ltd., 1947;, p. 111.
Teschan, P. E. ; Post, R. S., and Smith, L. H., Jr.:  Metabolic Behavior of Patients with Post-Traumatic Renal Insufficiency , Clin. Res. Proc. 2:98-99 ( (April) ) 1954;.
Swann, R. C, and Merrill, J, P.:  Clinical Course of Acute Renal Failure , Medicine 32:215-292 ( (Sept.) ) 1953;.
Murray, G. ; Delorme, E., and Thomas, N.:  Development of Artificial Kidney: Experimental and Clinical Experiences , Arch. Surg. 55:505-522 ( (Nov.) ) 1947;.
Alwall, N. ; Noviit, L., and Steins, A. M.:  On Artificial Kidney: VII. Clinical Experiences of Dialytic Treatment of Uremia , Acta med. scandinav. 132:587-602, 1949;.
Swan, H., and Gordon, H. H.:  Peritoneal Lavage in Treatment of Anuria in Children , Pediatrics 4:586-595 ( (Nov.) ) 1949;.
Skeggs, L. T., Jr. ; Leonards, J. R., and Heisler, C. R.:  Artificial Kidney: II. Construction and Operation of Improved Continuous Dialyzer , Proc. Soc. Exper. Biol. & Med. 72:539-543 ( (Dec.) ) 1949;.
Lowsley, O. S., and Kirwin, T. J.:  Artificial Kidney: Preliminary Report , J. Urol. 65:163-176 ( (Feb.) ) 1951;.
Rosenak, S. S., and Saltzman, A.:  New Dialyzer for Use as Artificial Kidney , Proc. Soc. Exper. Biol. & Med. 76:471-475 ( (March) ) 1951;.
Guarino, J. R., and Guarino, L. J.:  Artificial Kidney—A Simplified Apparatus , Science 115:285-288 ( (March 14) ) 1952;.
Goldner, F. ; Gordon, G. L., and Danzig, L. E.:  Use of Artificial Kidney in Chronic Renal Disease , A. M. A. Arch. Int. Med. 93:61-74 ( (Jan.) ) 1954;.
Doolan, P. D. ; Walsh, W. P.; Kyle, L. H., and Wishinsky, H.:  Acetylsalicylic Acid Intoxication: A Proposed Method of Treatment , J. A. M. A. 146:105-106 ( (May 12) ) 1951;.
Walsh, W. P.; Kyle, L. H.; Doolan, P. D., and Jeghers, H. J.:  Treatment of Barbiturate Poisoning by Hemodialysis , Am. J. Med. 13:104-105 ( (July) ) 1952;.
Merrill, J. P., and Weiler, J. M.:  Treatment of Bromism with Artificial Kidney , Ann. Int. Med. 37:186-190 ( (July) ) 1952;.
Danowski, T. S., and Elkinton, J. R.: Body Fluids: Basic Physiology and Practical Therapeutics , Baltimore, Williams & Wilkins Company, to be published.
Danowski, T. S.; Greenman, L.; Mateer. F. M. ; Parsons, W. B. ; Weigand, F. A. ; Mer- melstein, H., and Peters, J. H.:  Carboxylic Cation Exchange Resin Effects in Dogs , J. Clin. Invest. 30:984-994 ( (Sept.) ) 1951;.
Merrill, J. P. ; Levine, H. D. ; Somerville, W., and Smith, S.:  Clinical Recognition and Treatment of Acute Postassium Intoxication , Ann. Int. Med. 33:797-830 ( (Oct.) ) 1950;.
Hoff, H. E.; Smith, P. K., and Winkler, A. W.:  The Cause of Death in Experimental Anuria , J. Clin. Invest. 20:607-624 ( (Nov.) ) 1941;.
Kohn, R. M., and Kiley, J. E.:  Electrocardiographic Changes During Hemodialysis with Observations on Contribution of Electrolyte Disturbances to Digitalis Toxicity , Ann. Int. Med. 38:36-50 ( (July) ) 1953;.

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References

Rhoads, J. E.:  Peritoneal Lavage in Treatment of Renal Insufficiency , Acad. M. Sc. 196:642-647 ( (Nov.) ) 1938;.
Odel, H. M.; Ferris, D. 0., and Power, M. H.:  Peritoneal Lavage as Effective Means of Extrarenai Excretion: Clinical Appraisal , Am. J. Med. 9:63-77 ( (July) ) 1950;.
Muirhead, E. E. ; Small, A. B. ; Haley, A. E., and Hill, J. M.:  Peritoneal Irrigation for Acute Renal Damage Following Incompatible Blood Transfusion: Discussion Based on 3 Cases , J. Lab. & Clin. Med. 32:988-1001 ( (Aug.) ) 1947;.
Abel, J. J. ; Rowntree, L. C, and Turner, B. B.:  On the Removal of Diffusible Substances from the Circulating Blood of Living Animals by Dialysis , J. Pharmacol. & Exper. Therap. 5:275-316 ( (Jan.) ) 1913-1914;.
Necheles, H.:  Über dialysieren des stomenden blutes and lebenden , Klin. Wchnschr. 2:1257 ( (July 2) ) 1923;.
Darmady, E. M.:  Dialysis of Blood for Treatment of Uremia , Proc. Roy. Soc. Med. 41:418-419 ( (Jan. 22) ) 1928;.
Kolff, W. J., and Berk, H. T. J.:  Artificial Kidney: Dialyser with Great Area , Acta. med. scandinav. 117:121-134, 1944;.
Alwall, N.:  On Artificial Kidney: XI. Some Supplementary Constructional Details of Dialyser Intended for Rabbit and Homo , Acta. med. scandinav. (Supp. 229) , pp. 20-21, 1949;.
Kolff, W. J.: New Ways of Treating Uraemia: Artificial Kidney, Peritoneal Lavage, Intestinal Lavage , London, J. & A. Churchill, Ltd., 1947;, p. 111.
Teschan, P. E. ; Post, R. S., and Smith, L. H., Jr.:  Metabolic Behavior of Patients with Post-Traumatic Renal Insufficiency , Clin. Res. Proc. 2:98-99 ( (April) ) 1954;.
Swann, R. C, and Merrill, J, P.:  Clinical Course of Acute Renal Failure , Medicine 32:215-292 ( (Sept.) ) 1953;.
Murray, G. ; Delorme, E., and Thomas, N.:  Development of Artificial Kidney: Experimental and Clinical Experiences , Arch. Surg. 55:505-522 ( (Nov.) ) 1947;.
Alwall, N. ; Noviit, L., and Steins, A. M.:  On Artificial Kidney: VII. Clinical Experiences of Dialytic Treatment of Uremia , Acta med. scandinav. 132:587-602, 1949;.
Swan, H., and Gordon, H. H.:  Peritoneal Lavage in Treatment of Anuria in Children , Pediatrics 4:586-595 ( (Nov.) ) 1949;.
Skeggs, L. T., Jr. ; Leonards, J. R., and Heisler, C. R.:  Artificial Kidney: II. Construction and Operation of Improved Continuous Dialyzer , Proc. Soc. Exper. Biol. & Med. 72:539-543 ( (Dec.) ) 1949;.
Lowsley, O. S., and Kirwin, T. J.:  Artificial Kidney: Preliminary Report , J. Urol. 65:163-176 ( (Feb.) ) 1951;.
Rosenak, S. S., and Saltzman, A.:  New Dialyzer for Use as Artificial Kidney , Proc. Soc. Exper. Biol. & Med. 76:471-475 ( (March) ) 1951;.
Guarino, J. R., and Guarino, L. J.:  Artificial Kidney—A Simplified Apparatus , Science 115:285-288 ( (March 14) ) 1952;.
Goldner, F. ; Gordon, G. L., and Danzig, L. E.:  Use of Artificial Kidney in Chronic Renal Disease , A. M. A. Arch. Int. Med. 93:61-74 ( (Jan.) ) 1954;.
Doolan, P. D. ; Walsh, W. P.; Kyle, L. H., and Wishinsky, H.:  Acetylsalicylic Acid Intoxication: A Proposed Method of Treatment , J. A. M. A. 146:105-106 ( (May 12) ) 1951;.
Walsh, W. P.; Kyle, L. H.; Doolan, P. D., and Jeghers, H. J.:  Treatment of Barbiturate Poisoning by Hemodialysis , Am. J. Med. 13:104-105 ( (July) ) 1952;.
Merrill, J. P., and Weiler, J. M.:  Treatment of Bromism with Artificial Kidney , Ann. Int. Med. 37:186-190 ( (July) ) 1952;.
Danowski, T. S., and Elkinton, J. R.: Body Fluids: Basic Physiology and Practical Therapeutics , Baltimore, Williams & Wilkins Company, to be published.
Danowski, T. S.; Greenman, L.; Mateer. F. M. ; Parsons, W. B. ; Weigand, F. A. ; Mer- melstein, H., and Peters, J. H.:  Carboxylic Cation Exchange Resin Effects in Dogs , J. Clin. Invest. 30:984-994 ( (Sept.) ) 1951;.
Merrill, J. P. ; Levine, H. D. ; Somerville, W., and Smith, S.:  Clinical Recognition and Treatment of Acute Postassium Intoxication , Ann. Int. Med. 33:797-830 ( (Oct.) ) 1950;.
Hoff, H. E.; Smith, P. K., and Winkler, A. W.:  The Cause of Death in Experimental Anuria , J. Clin. Invest. 20:607-624 ( (Nov.) ) 1941;.
Kohn, R. M., and Kiley, J. E.:  Electrocardiographic Changes During Hemodialysis with Observations on Contribution of Electrolyte Disturbances to Digitalis Toxicity , Ann. Int. Med. 38:36-50 ( (July) ) 1953;.

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