Diaper rash (ammonia dermatitis) has been demonstrated to be caused by urea-splitting organisms which act on the urine to produce ammonia.1 Several antiseptics have been reported to be effective against these bacteria.
The reports * that poisoning of infants occurred by transcutaneous absorption of boric acid used as an ointment or powder on areas of diaper rash stimulated us to make a further selective evaluation of the toxicity and efficacy of the antiseptic methylbenzethonium chloride in controlling diaper rash and intertrigo. Available commercially,† the antiseptic was studied in the form of a dusting powder‡ and in an ointment.§
GENERAL PLAN OF STUDY
Methylbenzethonium chloride diaper rinse and the ointment were already patch-tested and reported on.∥ The following plan of study was therefore adopted.
Bacteriological studies against urea-splitting organisms of corn starch and 1: 1800 methylbenzethonium chloride applied as a dusting powder.
Sensitivity studies of dusting powder applied to