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Hydralazine in Nephritic Normal Children with Renal Hemodynamic Studies

JAMES N. ETTELDORF, M.D.; J. D. SMITH, M.D.; C. P. THARP, M.D.; A. H. TUTTLE, M.D.
AMA Am J Dis Child. 1955;89(4):451-462. doi:10.1001/archpedi.1955.02050110541007.
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INTRODUCTION  During recent years several therapeutic agents have been made available for use in the control of hypertension. One of these, hydralazine (Apresoline), has been widely used in adults. Because of the reported dual capacity of reducing blood pressure and at the same time increasing the renal blood flow in patients with hypertensive disorders,* hydralazine appeared to be an ideal agent in the management of hypertension associated with acute glomerulonephritis. For this reason the following study was undertaken to evaluate the clinical usefulness of this drug and its influence on renal hemodynamics in normal children and in children during the hypertensive phase of acute and chronic nephritis.These studies were being conducted at the same time that McCrory and Rapoport4 were investigating this agent. They have reported the effects of hydralazine on blood pressure and renal function in seven children with acute nephritis, two of whom were in the

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