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Piperazine in the Treatment of Enterobiasis

AMA Am J Dis Child. 1955;89(3):346-349. doi:10.1001/archpedi.1955.02050110412013.
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Enterobiasis is the most common helminth infestation in the United States. The pinworm has proved to be a difficult parasite to eradicate for the human race. Although reports of therapeutic agents have filled the medical literature throughout the years, not one drug has been universally accepted. Cram1 gave the following criteria for a satisfactory agent:

  1. The drug must be highly effective in removing pinworms.

  2. The drug must be relatively nontoxic, so that it can be given in repeated treatments over a period during which viable pinworm ova may be present in the patient's surroundings, the repeated administration of the drug also assuring its entrance into the cecum and appendix, common sites of pinworm infection.

  3. The treatment must be of such reasonable cost that its use in large families will not be prohibitive.

  4. The treatment must be so easily administered that it can be used with


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