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Distribution of Lead in Blood as Affected by Edathamil Calcium-Disodium

SAMUEL P. BESSMAN, M.D.; ENNIS C. LAYNE Jr., M.D.
AMA Am J Dis Child. 1955;89(3):292-294. doi:10.1001/archpedi.1955.02050110358005.
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The effectiveness of edathamil calciumdisodium (calcium disodium ethylenediamine tetraacetate [Ca EDTA] ) in stimulating the excretion of lead * suggests that it must exert a profound influence upon the binding of lead to tissue sites.

The experiments to be reported were designed to determine whether a redistribution of lead from cells to extracellular fluid does occur during the therapy of lead poisoning.

EXPERIMENTAL DATA  Patients with history, physical examination, and bone x-ray changes suggestive of lead poisoning were treated with edathamil calcium-disodium subcutaneously, a single 1 gm. dose as a 1% solution in saline. Blood specimens were drawn and heparinized at intervals up to eight hours and separated into plasma and cells. Lead was determined on aliquots of blood and urine by a semimicro modification of the colorimetric diphenylthiocarbazone (Dithizone) method developed in this laboratory.9 Five patients were studied, including three children and two adults. Data on the entire course of

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