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AMA Am J Dis Child. 1955;89(2):221-225. doi:10.1001/archpedi.1955.02050110263014.
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SICKLE-CELL anemia is a congenital and hereditary disease occurring almost exclusively in Negroes. In the United States it has been estimated that between 30,000 and 100,000 persons have the disease.1 Since the average age of onset of symptoms is 3 to 5 years,2 the disease presents a problem in pediatric practice.

The symptomatology and pathology of sickle-cell anemia are extremely diverse. Although much has been written regarding its manifestations in the cardiovascular system, the integument, the central nervous system, and the skeletal system, there have been very few reports of its renal manifestations. The current textbooks of hematology and urology fail to mention sickle-cell anemia as an etiologic factor in renal pathology. Recently several articles dealing with hematuria as a manifestation of sickle-cell anemia have appeared in journals of urology and internal medicine, but no such reports have appeared heretofore in the pediatric literature. It was felt that


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