IN PART I of this article it was pointed out that a definitive approach to the problem of the anemia of prematurity requires quantitative data concerning total body hemoglobin and red cell content and that basic to such measurements is knowledge of the blood volume of the premature infant. In the present study this aspect was investigated.
MATERIALS AND METHODS
Blood volume determinations were performed in 38 prematurely born infants ranging in age from 1 to 94 days. The birth weights of these infants ranged from 1,070 to 2,300 gm., and the weights at the time of blood volume estimation, from 1,270 to 3,800 grams. The infants studied had presented an uncomplicated course in the premature nursery and had given no evidence of infection or of disturbance in hydration or nutrition. Transfusions had not been given to any of the infants studied. The determinations were performed three hours after a