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STUDIES ON THE ANEMIA OF PREMATURITY

IRVING SCHULMAN, M.D.; CARL H. SMITH, M.D.; GERTRUDE S. STERN, M.D.; Eleanor Fort, B.S.; Beatrice Bennem, B.S.; Joyce Prestwidge, B.A.
AMA Am J Dis Child. 1954;88(5):567-568. doi:10.1001/archpedi.1954.02050100569001.
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ABSTRACT

ALTHOUGH the anemia of prematurity has long commanded the attention of pediatricians, there still exists a striking lack of agreement concerning most aspects of this syndrome. Many diverse theories relating to the pathogenesis of the anemia of premature infants are still taught, and many diverse modes of prophylaxis and therapy are based upon these theories. Thus the anemia has been variously considered to result from (1) excessive hemolysis,* (2) deficient antenatal stores of hematopoietic factors,3 (3) bone marrow immaturity,† and (4) rapid growth and hemodilution.6 The opinions concerning the role of iron in the etiology, prophylaxis, and therapy of the anemia of prematurity are equally variable and range from those which claim no value of iron whatever to those which claim striking benefit.‡ The value of blood transfusion in the management of the anemia of prematurity likewise remains a point of current debate, with widely divergent practices employed

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