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FERROUS SULFATE POISONING

WILLIAM M. CLARK Jr., M.D.; SEYMOUR S. JUROW, M.D.; ROY L. WALFORD, M.D.; ROBERT O. WARTHEN, M.D.
AMA Am J Dis Child. 1954;88(2):220-226. doi:10.1001/archpedi.1954.02050100222010.
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TOXIC effects from the ingestion of large doses of medicinal iron preparations have received increasing attention since 1947. when Forbes1 reported two fatal cases. Since his report, 24 additional cases have appeared in the medical literature.* In all, 25 infants and 1 adult were involved. Ferrous sulfate was ingested in 25 cases and ferric chloride in 1 case. Thirteen cases were fatal, and in 13 there was recovery. There seems to have been no direct correlation between the amount of iron ingested and the final outcome, since the ingestion of as little as 3.0 gm. of ferrous sulfate has terminated fatally,8 whereas the ingestion of 15.0 gm. has resulted in an uneventful recovery.11

Case 1 of the present study recovered after the ingestion of 2.4 gm. of ferrous sulfate. In Case 2, the ingestion of 10.2 to 14.2 gm. of ferrous sulfate proved fatal. The typical biphasic

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