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ISONIAZID IN TREATMENT OF TUBERCULOSIS IN CHILDHOOD

EDWIN L. KENDIG JR., M.D.; G. EARL TREVATHAN, M.D.; RALPH OWNBY JR., M.D.
AMA Am J Dis Child. 1954;88(2):148-157. doi:10.1001/archpedi.1954.02050100150002.
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THE ADVENT of streptomycin as a therapeutic agent in tuberculosis has caused considerable modification of the previously hopeless prognosis which attended the diagnosis of tuberculous meningitis in children. As pointed out in a recent study,1 however, the results of treatment with this drug in conjunction with either thiazolsulfone (Promizole) or paraaminosalicylic acid have been far short of the desired goal. Further, there has remained this ever-present question: When should one use streptomycin in the treatment of the lesser forms of tuberculosis in childhood?

Since there are many questions not completely answered and since isoniazid has been demonstrated to be a promising tuberculostatic compound, it has seemed advisable to continue the clinical use of this agent in the treatment of the various forms of tuberculosis as the disease appears in children. The Committee on Chemotherapy and Antibiotics of the American College of Chest Physicians2 feels that "isoniazid has not

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