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HEMOLYSIS IN INFANTS FOLLOWING ADMINISTRATION OF POOLED PLASMA

HANS G. KEITEL, M.D.; J. WICH, M.D.
AMA Am J Dis Child. 1954;87(5):537-542. doi:10.1001/archpedi.1954.02050090525001.
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INTRODUCTION  SINCE the advent of pooled plasma * in therapy there have been divergent opinions as to its complete safety. Its administration has been attended by immediate febrile and urticarial reactions † and by late hepatic complications,5 but there has been some question concerning hemolytic reactions in recipients whose blood group is either A, B, or AB. The hemolysis presumably is due to alpha or beta hemolysins which are normally present in plasma.‡ Several reports show that nonpooled plasma having a high titer of alpha hemolysins is capable of producing a hemolytic reaction.§ Although many pooled-plasma transfusions have been given without the development of overt clinical manifestations, the possibility remains that the transfusions of blood-group isoantibodies can produce hemolysis if they are present in high titer or if a large amount of plasma containing a low titer of agglutinins is administered.‖ It is the purpose of this report to describe

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