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November 1953, Vol 86, No. 5 >
Article | November 1953

BILATERAL OPTIC NEURITIS FOLLOWING SMALLPOX VACCINATION AND DIPHTHERIA-TETANUS TOXOID FREE

WILLIAM U. McREYNOLDS, M.D.; WILLIAM H. HAVENER, M.D.; MANOS A. PETROHELOS, M.D.
AMA Am J Dis Child. 1953;86(5):601-603. doi:10.1001/archpedi.1953.02050080614006.
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OPTIC NEURITIS accompanying encephalitis is a rare but well-established complication of smallpox and antirabic vaccination.1 Optic neuritis without central symptoms is, however, an extremely rare complication of immunization procedures. Duke-Elder,2 noting the reports of Cormack and Anderson 3 and Hasabe,4 states that "a severe neuritis without necessarily other central symptoms but involving abolition of light may follow an antirabic inoculation." In 1949, Ross5 decribed one case and Siegert6 three cases of bilateral optic neuritis following the administration of diphtheria toxoid. Following is the report of a case of bilateral optic neuritis which followed simultaneous smallpox vaccination and combined diphtheria-tetanus toxoid administration.

REPORT OF CASE  A 7-year-old white girl was brought to the hospital on May 13, 1952, complaining of a sudden decrease in visual acuity of three days' duration. She had no other complaints, and her parents had noted no symptoms of any illness. Further

REFERENCES

1 +
Duke-Elder, W. S.: Text-Book of Ophthalmology , St. Louis, 1940;, Vol. 3, pp. 2992-2993.
2 +
Walsh, F. B.: Clinical Neuro-Ophthalomolgy , Baltimore, Williams & Wilkins Company, 1947;, pp. 562-563.
3 +
Duke-Elder,1a p. 2997.
4 +
Cormack, H. S., and Anderson, L. A. P.:  Bilateral Papillitis Following Antirabic Inoculation: Recovery , Brit. J. Ophth. 18:167 ( (March) ) 1934;.
5 +
Hasabe, cited by Duke-Elder.1
6 +
Ross, J. V. M.:  Bilateral Optic Neuritis with Partial Internal Ophthalmoplegia Following Administration of Diphtheria Toxoid , Alum Precipitated, Refined, Eye, Ear, Nose & Throat Month. 28:119 ( (March) ) 1949;.
7 +
Siegert, P.:  Sehnervenerkrankungen nach Diphtherieschutzimpfung , Deutsche med. Wchnschr. 74:769 ( (June 17) ) 1949;.
8 +
Rosen, E.:  The Significance of Ocular Complications Following Vaccination , Brit. J. Ophth. 33:358 ( (June) ) 1949;.
9 +
Winkelman, N. W., Jr.:  Peripheral Nerve and Root Disturbances Following Vaccination Against Smallpox: Study of 5 Cases , Arch. Neurol. & Psychiat. 62:421 ( (Oct.) ) 1949;.
10 +
Quinn, J. R., and Wolfson, W. Q.:  Improved Results from Individualized Intensive Hormonal Treatment in Certain Eye Diseases Reported to Respond Poorly to ACTH or Cortisone , Univ. Michigan M. Bull. 18:1 ( (Jan.) ) 1952;.

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References

1 +
Duke-Elder, W. S.: Text-Book of Ophthalmology , St. Louis, 1940;, Vol. 3, pp. 2992-2993.
2 +
Walsh, F. B.: Clinical Neuro-Ophthalomolgy , Baltimore, Williams & Wilkins Company, 1947;, pp. 562-563.
3 +
Duke-Elder,1a p. 2997.
4 +
Cormack, H. S., and Anderson, L. A. P.:  Bilateral Papillitis Following Antirabic Inoculation: Recovery , Brit. J. Ophth. 18:167 ( (March) ) 1934;.
5 +
Hasabe, cited by Duke-Elder.1
6 +
Ross, J. V. M.:  Bilateral Optic Neuritis with Partial Internal Ophthalmoplegia Following Administration of Diphtheria Toxoid , Alum Precipitated, Refined, Eye, Ear, Nose & Throat Month. 28:119 ( (March) ) 1949;.
7 +
Siegert, P.:  Sehnervenerkrankungen nach Diphtherieschutzimpfung , Deutsche med. Wchnschr. 74:769 ( (June 17) ) 1949;.
8 +
Rosen, E.:  The Significance of Ocular Complications Following Vaccination , Brit. J. Ophth. 33:358 ( (June) ) 1949;.
9 +
Winkelman, N. W., Jr.:  Peripheral Nerve and Root Disturbances Following Vaccination Against Smallpox: Study of 5 Cases , Arch. Neurol. & Psychiat. 62:421 ( (Oct.) ) 1949;.
10 +
Quinn, J. R., and Wolfson, W. Q.:  Improved Results from Individualized Intensive Hormonal Treatment in Certain Eye Diseases Reported to Respond Poorly to ACTH or Cortisone , Univ. Michigan M. Bull. 18:1 ( (Jan.) ) 1952;.

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