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October 1953, Vol 86, No. 4 >
Article | October 1953

Growth and Metabolism in Normal and Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta): V. Roentgenographic Features of Skeletal Development in Normal and Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta) FREE

LEE B. LUSTED, M.D; DONALD E. PICKERING, M.D.; DELBERT FISHER, M.D.; FRANCIS SCOTT SMYTH, M.D.
[+] Author Affiliations

This investigation was principally supported by a research grant from the Playtex Park Foundation to the Department of Pediatrics.


AMA Am J Dis Child. 1953;86(4):426-435. doi:10.1001/archpedi.1953.02050080438004.
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References
Comments

IT IS THE purpose of this paper to integrate roentgenologic features of skeletal growth and development in normal and athyroid infant rhesus monkeys with previously reported studies of growth and metabolism in the same animals.1

In the present study, skeletal growth and maturation were evaluated by serial roentgenograms. The roentgenologic features of thyroid deficiency in humans are well described.2 These features, however, have not previously been investigated in subhuman primates.

METHODS AND MATERIALS  Animals.—Six infant rhesus monkeys whose lineage was carefully recorded were obtained for our studies from the indoor macaque colony of Dr. van Wagenen at Yale University.1aAnimals D-766 and C-794 were used as controls throughout the study, while Animal B-767 was used as a third normal control until the age of 162 days at which time it received a thyroid-ablating dose of 1.5 mc. of I131.1b Animal B-767 was thereafter included in

REFERENCES

1 +
Pickering, D. E.; Smyth, F. S.; van Wagenen, G., and Fisher, D. A.:  Growth and Metabolism in Normal and Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta): I. Growth and Metabolism in Normal Infant Rhesus Monkeys (Macaca Mulatta) , A. M. A. Am. J. Dis. Child. 86:1, 1953;.
2 +
Pickering, D. E., and Fisher, D. A.:  II. Growth and Metabolism in Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta) , A. M. A. Am. J. Dis. Child. 86:11, 1953;.
3 +
Pickering, D. E., and Fisher, D. A.:  III. Growth and Metabolism Following l-Thyroxine Administration in Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta) , A. M. A. Am. J. Dis. Child. , 86:147, 1953;.
4 +
Pickering, D. E.; Fisher, D. A., and Scott, K. G.: IV. Radiosodium (Na24) Space in Normal and Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta), A. M. A. Am. J. Dis. Child. 86:157, 1953.
5 +
Pickering, D. E.; Fisher, D. A., and Scott, K. G.:  VI. Iodine Metabolism in Normal and Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta) , A. M. A. Am. J. Dis. Child. 1953;86157, to be published.
6 +
Crane, J.; Pickering, D. E., and Smyth, F. S.: VII. Histopathology of Normal and Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta), A. M. A. Am. J. Dis. Child. 1953 86 157, to be published.
7 +
Caffey, J.: Pediatric X-Ray Diagnosis: Textbook for Students and Practitioners of Pediatrics, Surgery & Radiology , Chicago, Year Book Publishers, Inc., 1950;.
8 +
Schinz, H. R.; Baensch, W. E.; Friedl, E., and Uehlinger, E.: Roentgen-Diagnostics, English translation of Fifth German edition edited by J. T. Case, Vol. II, New York, Grune & Stratton, Inc., 1952;.
9 +
Wilkins, L.:  The Rates of Growth, Osseous Development, and Mental Development in Cretins as a Guide to Thyroid Treatment , J. Pediat. 12:429, 1938;.
10 +
Footnotes 1 b and e.
11 +
Footnotes 1 b and f.
12 +
Footnotes 1 a, b, and c.
13 +
Miller, E. R.:  A Device for Immobilizing Children During Radiographic Examination , Radiology 58:421, 1952;.
14 +
Dr. Eldon Nickel, Dr. Earl Miller, and Dr. Donald E. Pickering are currently conducting studies relating to bone density in normal and pathological states.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Pickering, D. E.; Smyth, F. S.; van Wagenen, G., and Fisher, D. A.:  Growth and Metabolism in Normal and Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta): I. Growth and Metabolism in Normal Infant Rhesus Monkeys (Macaca Mulatta) , A. M. A. Am. J. Dis. Child. 86:1, 1953;.
2 +
Pickering, D. E., and Fisher, D. A.:  II. Growth and Metabolism in Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta) , A. M. A. Am. J. Dis. Child. 86:11, 1953;.
3 +
Pickering, D. E., and Fisher, D. A.:  III. Growth and Metabolism Following l-Thyroxine Administration in Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta) , A. M. A. Am. J. Dis. Child. , 86:147, 1953;.
4 +
Pickering, D. E.; Fisher, D. A., and Scott, K. G.: IV. Radiosodium (Na24) Space in Normal and Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta), A. M. A. Am. J. Dis. Child. 86:157, 1953.
5 +
Pickering, D. E.; Fisher, D. A., and Scott, K. G.:  VI. Iodine Metabolism in Normal and Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta) , A. M. A. Am. J. Dis. Child. 1953;86157, to be published.
6 +
Crane, J.; Pickering, D. E., and Smyth, F. S.: VII. Histopathology of Normal and Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta), A. M. A. Am. J. Dis. Child. 1953 86 157, to be published.
7 +
Caffey, J.: Pediatric X-Ray Diagnosis: Textbook for Students and Practitioners of Pediatrics, Surgery & Radiology , Chicago, Year Book Publishers, Inc., 1950;.
8 +
Schinz, H. R.; Baensch, W. E.; Friedl, E., and Uehlinger, E.: Roentgen-Diagnostics, English translation of Fifth German edition edited by J. T. Case, Vol. II, New York, Grune & Stratton, Inc., 1952;.
9 +
Wilkins, L.:  The Rates of Growth, Osseous Development, and Mental Development in Cretins as a Guide to Thyroid Treatment , J. Pediat. 12:429, 1938;.
10 +
Footnotes 1 b and e.
11 +
Footnotes 1 b and f.
12 +
Footnotes 1 a, b, and c.
13 +
Miller, E. R.:  A Device for Immobilizing Children During Radiographic Examination , Radiology 58:421, 1952;.
14 +
Dr. Eldon Nickel, Dr. Earl Miller, and Dr. Donald E. Pickering are currently conducting studies relating to bone density in normal and pathological states.

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