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August 1953, Vol 86, No. 2 >
Article | August 1953

CONGENITAL MYASTHENIA GRAVIS FREE

RHETT P. WALKER, M.D.
AMA Am J Dis Child. 1953;86(2):198-200. doi:10.1001/archpedi.1953.02050080207008.
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MYASTHENIA gravis is rare, but does occur in the newborn. In the child of a myasthenic mother one occasionally sees the typical clinical picture. If the child survives the neonatal period, the disease disappears spontaneously in a few days or weeks.

The other type of myasthenia gravis occurring in the newborn is rarer and occurs in children born of healthy mothers. Their disease resembles the adult type and tends to be permanent. It is the purpose of this communication to report such a case.

REPORT OF CASE  A 2-month-old white girl was admitted to the Children's Hospital on Nov. 27, 1951, for study of respiratory difficulty and inability to nurse.There was no family history of myasthenia gravis or other muscular or nervous diseases. Gestation was remarkable in that the mother was intimately exposed to an acute case poliomyelitis early in her pregnancy. Delivery was preceded by a week of

REFERENCES

1 +
Mackay, R. I.:  Congenital Myasthenia Gravis , Arch. Dis. Childhood 26:289-293 ( (Aug.) ) 1951;.
2 +
Bowman, J. R.:  Myasthenia Gravis in Young Children: Report of Three Cases—One Congenital , Pediatrics 1:472-477 ( (April) ) 1948;.
3 +
Levin, P. M.:  Congenital Myasthenia in Siblings , Arch. Neurol. & Psychiat. 62:745-758 ( (Dec.) ) 1949;.
4 +
Nilsby, J.:  Myasthenia Gravis of Newborn Child , Acta pædiat. 37:489-492, 1949;.
5 +
Strickroot, F. L.; Schaffer, R. L., and Bergo, H. L.:  Myasthenia Gravis Occurring in Infant Born of Myasthenic Mother , J. A. M. A. 120:1207-1209 ( (Dec. 12) ) 1942;.
6 +
Geddes, A. K., and Kidd, H. M.:  Myasthenia Gravis of Newborn , Canad. M. A. J. 64:152-156 ( (Feb.) ) 1951;.
7 +
LaBranche, H. G., and Jefferson, R. N.:  Congenital Myasthenia Gravis , Pediatrics 4:16-20 ( (July) ) 1949;.
8 +
Viets, H. R. and Brown, M. R.:  Medical Progress: Diseases of Muscles , New England J. Med. 245:647-653 ( (Oct. 25) ) 1951;.
9 +
McKeever, G. E.:  Myasthenia Gravis in a Mother and Her Newborn Son , J. A. M. A. 147:320-322 ( (Sept. 22) ) 1951;.

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References

1 +
Mackay, R. I.:  Congenital Myasthenia Gravis , Arch. Dis. Childhood 26:289-293 ( (Aug.) ) 1951;.
2 +
Bowman, J. R.:  Myasthenia Gravis in Young Children: Report of Three Cases—One Congenital , Pediatrics 1:472-477 ( (April) ) 1948;.
3 +
Levin, P. M.:  Congenital Myasthenia in Siblings , Arch. Neurol. & Psychiat. 62:745-758 ( (Dec.) ) 1949;.
4 +
Nilsby, J.:  Myasthenia Gravis of Newborn Child , Acta pædiat. 37:489-492, 1949;.
5 +
Strickroot, F. L.; Schaffer, R. L., and Bergo, H. L.:  Myasthenia Gravis Occurring in Infant Born of Myasthenic Mother , J. A. M. A. 120:1207-1209 ( (Dec. 12) ) 1942;.
6 +
Geddes, A. K., and Kidd, H. M.:  Myasthenia Gravis of Newborn , Canad. M. A. J. 64:152-156 ( (Feb.) ) 1951;.
7 +
LaBranche, H. G., and Jefferson, R. N.:  Congenital Myasthenia Gravis , Pediatrics 4:16-20 ( (July) ) 1949;.
8 +
Viets, H. R. and Brown, M. R.:  Medical Progress: Diseases of Muscles , New England J. Med. 245:647-653 ( (Oct. 25) ) 1951;.
9 +
McKeever, G. E.:  Myasthenia Gravis in a Mother and Her Newborn Son , J. A. M. A. 147:320-322 ( (Sept. 22) ) 1951;.

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