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August 1953, Vol 86, No. 2 >
Article | August 1953

IV. Radiosodium (Na24) Space in Normal and Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta) FREE

DONALD E. PICKERING, M.D.; DELBERT A. FISHER, M.D.; KENNETH G. SCOTT, Ph.D.
[+] Author Affiliations

This investigation was principally supported by a research grant from the Playtex Park Foundation and also received support from the Edwards (Research No. 110) Fund of the University of California Medical School.


AMA Am J Dis Child. 1953;86(2):157-161. doi:10.1001/archpedi.1953.02050080166003.
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References
Comments

THE PURPOSE of this communication is to relate Na24 "space" data with previously reported growth and metabolic studies in normal and thyroid-ablated infant macaque monkeys.1

Na24 "space" was sought as a measure of one relatively constant increment of total body mass and was determined at varying intervals during growth and compared in normal and myxedematous subjects.

METHODS  Techniques of animal care and feeding have been reported in a previous communication.1a Radiosodium (Na24) was procured from the Oak Ridge National Laboratory, where it was prepared by neutron bombardment of sodium carbonate. The half-life of Na24 is 14.9 hours. Samples received in this laboratory were prepared as isotonic sterile solutions and diluted with 0.85% NaCl to contain approximately 10 μc per cubic centimeter at the time of animal injection. The quantity of isotope present in samples was determined with a scintillation counter. This was composed of

REFERENCES

1 +
Pickering, D. E.; Smyth, F. S.; Van Wagenen, G., and Fisher, D. A.:  Growth and Metabolism in Normal and Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta): I. Growth and Metabolism in Normal Infant Rhesus Monkeys (Macaca Mulatta) , A. M. A. Am. J. Dis. Child . 86:1, 1953;.
2 +
Pickering, D. E.; Fisher, D. A., and Smyth, F. S.:  II. Growth and Metabolism in Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta) , A. M. A. Am. J. Dis. Child 86:11, 1953;.
3 +
Pickering, D. E., and Fisher, D. A.:  III. Growth and Metabolism Following l-Thyroxine Administration in Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta) , A. M. A. Am. J. Dis. Child 1953;86, this issue, p. 147.
4 +
Lusted, L.; Pickering, D. E.; Fisher, D. A., and Smyth, F. S.: V. Roentgenographic Features of Skeletal Development in Normal and Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta), ibid., to be published.
5 +
Pickering, D. E.; Fisher, D. A., and Scott, K. G.: VI. Iodine Metabolism in Normal and Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta), ibid., to be published.
6 +
Crane, J.; Pickering, D. E., and Smyth, F. S.: VII. Histopathology of Normal and Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta), ibid., to be published.
7 +
Bowers, J. Z., and Scott, K. G.:  Distribution and Excretion of Electrolytes After Acute Whole-Body Irradiation Injury: Studies with Radiosodium , Proc. Soc. Exper. Biol. & Med. 78:648, 1951;.
8 +
Fellers, F. X.; Barnett, H. L.; Hare, K., and McNamara, H.:  Change in Thiocyanate and Sodium24 Spaces During Growth , Pediatrics 3:622, 1949;.
9 +
Forbes, G. B., and Perley, A. M.:  Estimation of Total Body Sodium by Isotopic Dilution: I. Studies on Young Adults , J. Clin. Invest. 30:558, 1951;.
10 +
Forbes, G. B., and Perley, A. M.:  Estimation of Total Body Sodium by Isotopic Dilution: II. Studies on Infants and Children; An Example of a Constant Differential Growth Ratio , J. Clin. Invest. 30:566, 1951;.
11 +
Manery, J. F., and Bale, W. F.:  The Penetration of Radioactive Sodium and Phosphorus into the Extra- and Intracellular Phases of Tissues , Am. J. Physiol. 132:215, 1941;.
12 +
Hahn, L. A.; Hevesy, G. C., and Rebbe, O. H.;  Do the Potassium Ions Inside the Muscle Cells and Blood Corpuscles Exchange with Those Present in the Plasma? Biochem. J. 33:1549, 1939;.
13 +
Kaltreider, N. L.; Meneely, G. R.; Allen, J. R., and Bale, W. F.:  Determination of the Volume of the Extracellular Fluid of the Body with Radioactive Sodium , J. Exper. Med. 74:569, 1941;.
14 +
Edelman, I. S.; James, A. H., and Moore, F. D.: The Location and the Turnover of the Sodiums of Bone, in Conference on Metabolic Interrelations: Metabolic Interrelations with Special Reference to Calcium; Transactions of the Fourth Conference; Jan. 7-8, 1952, edited by E. C. Reifenstein, Jr., New York, Josiah Macy, Jr., Foundation, 1952, p. 240.
15 +
Footnote 4a and c.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Pickering, D. E.; Smyth, F. S.; Van Wagenen, G., and Fisher, D. A.:  Growth and Metabolism in Normal and Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta): I. Growth and Metabolism in Normal Infant Rhesus Monkeys (Macaca Mulatta) , A. M. A. Am. J. Dis. Child . 86:1, 1953;.
2 +
Pickering, D. E.; Fisher, D. A., and Smyth, F. S.:  II. Growth and Metabolism in Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta) , A. M. A. Am. J. Dis. Child 86:11, 1953;.
3 +
Pickering, D. E., and Fisher, D. A.:  III. Growth and Metabolism Following l-Thyroxine Administration in Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta) , A. M. A. Am. J. Dis. Child 1953;86, this issue, p. 147.
4 +
Lusted, L.; Pickering, D. E.; Fisher, D. A., and Smyth, F. S.: V. Roentgenographic Features of Skeletal Development in Normal and Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta), ibid., to be published.
5 +
Pickering, D. E.; Fisher, D. A., and Scott, K. G.: VI. Iodine Metabolism in Normal and Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta), ibid., to be published.
6 +
Crane, J.; Pickering, D. E., and Smyth, F. S.: VII. Histopathology of Normal and Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta), ibid., to be published.
7 +
Bowers, J. Z., and Scott, K. G.:  Distribution and Excretion of Electrolytes After Acute Whole-Body Irradiation Injury: Studies with Radiosodium , Proc. Soc. Exper. Biol. & Med. 78:648, 1951;.
8 +
Fellers, F. X.; Barnett, H. L.; Hare, K., and McNamara, H.:  Change in Thiocyanate and Sodium24 Spaces During Growth , Pediatrics 3:622, 1949;.
9 +
Forbes, G. B., and Perley, A. M.:  Estimation of Total Body Sodium by Isotopic Dilution: I. Studies on Young Adults , J. Clin. Invest. 30:558, 1951;.
10 +
Forbes, G. B., and Perley, A. M.:  Estimation of Total Body Sodium by Isotopic Dilution: II. Studies on Infants and Children; An Example of a Constant Differential Growth Ratio , J. Clin. Invest. 30:566, 1951;.
11 +
Manery, J. F., and Bale, W. F.:  The Penetration of Radioactive Sodium and Phosphorus into the Extra- and Intracellular Phases of Tissues , Am. J. Physiol. 132:215, 1941;.
12 +
Hahn, L. A.; Hevesy, G. C., and Rebbe, O. H.;  Do the Potassium Ions Inside the Muscle Cells and Blood Corpuscles Exchange with Those Present in the Plasma? Biochem. J. 33:1549, 1939;.
13 +
Kaltreider, N. L.; Meneely, G. R.; Allen, J. R., and Bale, W. F.:  Determination of the Volume of the Extracellular Fluid of the Body with Radioactive Sodium , J. Exper. Med. 74:569, 1941;.
14 +
Edelman, I. S.; James, A. H., and Moore, F. D.: The Location and the Turnover of the Sodiums of Bone, in Conference on Metabolic Interrelations: Metabolic Interrelations with Special Reference to Calcium; Transactions of the Fourth Conference; Jan. 7-8, 1952, edited by E. C. Reifenstein, Jr., New York, Josiah Macy, Jr., Foundation, 1952, p. 240.
15 +
Footnote 4a and c.

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