July 1953, Vol 86, No. 1 >

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Article | July 1953

II. Growth and Metabolism in Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta)

DONALD E. PICKERING, M.D.; DELBERT A. FISHER, M.D.

AMA Am J Dis Child. 1953;86(1):11-22. doi:10.1001/archpedi.1953.02050080018002.

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THIS COMMUNICATION presents a study of infant rhesus monkeys rendered athyroid by I¹³¹ administration. Its justification rests upon the premise that a better understanding of the effects of thyroidectomy in infant catarrhine primates might broaden our understanding of human cretinism. Aberrations in growth and development and correlated metabolic changes following thyroid ablation are reported. This report is one of a series on the growth and development of normal and thyroid-ablated infant rhesus monkeys.1

Previously reported studies on effects of thyroidectomy in the young rhesus monkeys are limited to those of Fleischmann and co-workers.² They observed that while no other physical effects were seen, one of the two rhesus animals which they surgically thyroidectomized at 8 months (the other of which died within a few days following surgery) showed no appreciably significant growth during a 21-week survival period.

Earlier reports upon the effects of (surgical) thyroidectomy in adult rhesus

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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PICKERING DE, FISHER DA. II. Growth and Metabolism in Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta). AMA Am J Dis Child. 1953;86(1):11-22. doi:10.1001/archpedi.1953.02050080018002.

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