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H. G. DUNN, M.B., M.R.C.P., D.C.H.
AMA Am J Dis Child. 1953;85(6):655-674. doi:10.1001/archpedi.1953.02050070672004.
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IT IS GENERALLY agreed that hemolytic disease of the newborn is usually caused by antibodies formed in Rhesus-negative mothers against the Rh factor D (Rh0) of Rhesus-positive children. According to Wallerstein1 this mechanism accounts for 92%, according to Mollison2 for some 95%, of all cases of the disease. Of the remaining instances, a few are due to sensitization of the mother against one of the other Rh antigens or against an antigen belonging to a different blood group system such as Kell. This still leaves a residue of unexplained cases, and in many of these incompatibility of the major ABO blood groups has been held responsible.

By now a considerable number of instances of the disease attributed to maternal anti-A or anti-B antibodies has been recorded all over the world. In 1948, Grumbach and Gasser3 fully reviewed the literature of the subject and added nine cases


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