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USE OF CORTISONE AND CORTICOTROPIN (ACTH) IN TREATMENT OF RETICULOENDOTHELIOSIS IN CHILDREN

MURRAY H. BASS, M.D.; SAMUEL O. SAPIN, M.D.; HORACE L. HODES, M.D.
AMA Am J Dis Child. 1953;85(4):393-403. doi:10.1001/archpedi.1953.02050070407001.
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HAVING had the opportunity during the past three years of observing five children suffering from reticuloendotheliosis, we here wish to report the effect of corticotropin (ACTH) and cortisone on the course of this disease.

There has lately been renewed interest in the subject of reticuloendotheliosis in childhood, chiefly because a benign form of the disease, eosinophilic granuloma, has been described and shown to be related to previously-known clinical syndromes characterized by a much more serious prognosis.1 We refer to Hand-Schüller-Christian disease and the rarer Letterer-Siwe disease.2 It is not our purpose here to discuss at length the relationship of these three diseases; suffice it to say that there are now enough clinical descriptions of cases to warrant considering these diseases as due to the same underlying pathological process.3 There is still doubt in the minds of some as to this relationship,4 but the majority of pathologists

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