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August 1952, Vol 84, No. 2 >
Article | August 1952

LACK OF EFFECT OF SUPPLEMENTARY VITAMIN B12 ADMINISTERED TO PREMATURE INFANTS FREE

LAURENCE FINBERG, M.D.; BACON F. CHOW, Ph.D.
AMA Am J Dis Child. 1952;84(2):165-167. doi:10.1001/archpedi.1952.02050020029002.
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REPORTS of several investigators have indicated that vitamin B12 has growthpromoting properties.1 The possibility that this compound might be of especial benefit to premature infants, as an accelerator of growth and hematopoiesis, has been put to test by a number of clinics, with entirely negative results.2

The present study is concerned with 117 infants admitted to the premature nursery of Baltimore City Hospitals in 1950. Studies were made of the weight gain, the hemoglobin levels, and the red blood cell counts of two groups of premature infants; one group comprised infants who received a daily oral supplement of 30 μ of a solution of crystalline vitamin B12, and the other was a control group.

METHODS  Upon admission to the premature nursery infants were assigned alternately to the vitamin B12 group and to the control group. All infants received similar care during the first week of life.

REFERENCES

1 +
Wetzel, N. C.; Fargo, W. C.; Smith, I. H., and Helikson, J.:  Growth Failure in School Children as Associated with Vitamin B12 Deficiency: Response to Oral Therapy , Science 110:651, 1949;.
2 +
Chow, B. F.:  Sequelae to the Administration of Vitamin B12 to Humans , J. Nutrition 43:323, 1951;.
3 +
Downing, D. F.:  Failure of Vitamin B12 to Promote Growth of Premature Infants , Science 112:181, 1950;.
4 +
Rascoff, H.; Danewitz, A. and Norton, R.:  The Weight Progress of Premature Infants Given Supplementary Feedings of Vitamin B12 , J. Pediat. 39:61, 1951;.
5 +
Mitchell, T.; Etteldorf, J. N.; Tuttle, A. H., and Clayton, G. W.:  Crystalline Vitamin B12 and Sodium Folvate in Prematurity , Pediatrics 8:821, 1951;.
6 +
McCollum, E. B., and Chow, B. F.:  Sex Differences in the Weight-Stimulating Effect of B12 in Rats on Diets of Varying Composition , Proc. Soc. Exper. Biol. & Med. 75:20, 1950;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Wetzel, N. C.; Fargo, W. C.; Smith, I. H., and Helikson, J.:  Growth Failure in School Children as Associated with Vitamin B12 Deficiency: Response to Oral Therapy , Science 110:651, 1949;.
2 +
Chow, B. F.:  Sequelae to the Administration of Vitamin B12 to Humans , J. Nutrition 43:323, 1951;.
3 +
Downing, D. F.:  Failure of Vitamin B12 to Promote Growth of Premature Infants , Science 112:181, 1950;.
4 +
Rascoff, H.; Danewitz, A. and Norton, R.:  The Weight Progress of Premature Infants Given Supplementary Feedings of Vitamin B12 , J. Pediat. 39:61, 1951;.
5 +
Mitchell, T.; Etteldorf, J. N.; Tuttle, A. H., and Clayton, G. W.:  Crystalline Vitamin B12 and Sodium Folvate in Prematurity , Pediatrics 8:821, 1951;.
6 +
McCollum, E. B., and Chow, B. F.:  Sex Differences in the Weight-Stimulating Effect of B12 in Rats on Diets of Varying Composition , Proc. Soc. Exper. Biol. & Med. 75:20, 1950;.

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