THE REPORTS on the beneficial effects of methyltestosterone for premature infants vary. Shelton and Varden1 and Shelton, Varden, and Mark2 found it of benefit in two series of premature infants in decreasing the expected mortality, increasing the daily weight gain, and shortening the hospital stay. Hardy and Wilkins3 and Seitchik and Agerty4 in their two series did not find any beneficial results over ordinary nursery treatment of premature infants. Earle,5 using methyltestosterone and plasma orally, found them of benefit in increasing daily weight gain and in shortening the hospital stay; however he was unable to attribute his results to methyltestosterone alone, to plasma alone, or to the combination of methyltestosterone and plasma.
In an effort to evaluate further the use of methyltestosterone,6 50 premature infants, including four sets of twins, were studied. All premature infants were handled by a standard nursery regimen. Feedings consisted