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AMA Am J Dis Child. 1951;82(2):153-159. doi:10.1001/archpedi.1951.02040040162006.
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IDIOPATHIC familial hyperlipemia is a rare disorder. Hyperlipemia associated with certain known pathologic conditions is not uncommon; it may be found in cases of diabetes mellitus, certain diseases of the kidney, liver and pancreas, hypothyroidism, starvation, anemia, occlusive vascular disease, certain dermatoses, glycogenosis (von Gierke's disease) and Niemann-Pick disease. Only seven cases of idiopathic hyperlipemia in children are found in the literature,1 with an equal number in adults being reported.2 Bürger and Grütz1a (1932) described the first case, of an 11 year old boy with hyperlipemia, hepatosplenomegaly and a nodular xanthomatous skin eruption which appeared and disappeared with rise and fall of the blood lipid level. Opitz1b (1935) described a 12 year old boy with hyperlipemia and splenomegaly but without xanthomatous skin eruption. Franklin1c (1937) reported a case of a 5 year old girl who had no skin lesions but had splenomegaly and hyperlipemia. Bernstein


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