0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

EFFECTS OF STREPTOMYCIN UPON THE HUMAN FETUS

ALAN RUBIN, M.D.; JULIUS WINSTON, M.D.; MARY LOUISE RUTLEDGE, M.D.
AMA Am J Dis Child. 1951;82(1):14-16. doi:10.1001/archpedi.1951.02040040021003.
Text Size: A A A
Published online

ON SEVERAL occasions we have encountered a pregnant woman for whom the administration of streptomycin was deemed necessary for treatment of tuberculosis. Molitor and co-workers1 have reported that weanling rats given repeated doses of streptomycin showed a retardation of growth and pronounced nervous hyperexcitability. No such changes were noted in adult rats. These observations suggest that the immature organism may be more susceptible to the neurotoxic effects of streptomycin than the adult. Since streptomycin crosses the placenta,2 the possibility of fetal damage from prolonged administration of the drug required consideration. In the two clinical reports3 that have appeared, a total of seven infants whose mothers received streptomycin during pregnancy were studied. The infants were followed for two to 11 mo. after birth. All were said to be normal. However, apparently not all the infants had their vestibular function tested. Presented here are three additional cases in which

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();