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Mean percentage change in bone mineral density (BMD) from baseline by depot medroxyprogesterone acetate (DMPA) exposure status, adjusted for baseline covariates (BMD, ethnicity, pregnancy, age at menarche) and time-dependent covariates (age, smoking status, calcium intake, percentage body fat). Error bars represent 1 SE from the mean. New users (n = 17, 9, and 8 at 12, 18, and 24 months, respectively) received 1 DMPA injection; prevalent users (n = 26, 18, and 14 at 12, 18, and 24 months, respectively) received more than 1 DMPA injection. For DMPA discontinuers (n = 26, 14, and 5 at 12, 18, and 24 months, respectively), the intervals refer to the length of time participants were followed up after becoming discontinuers. The number of nonusers at 12, 18, and 24 months was 69, 69, and 59, respectively. A, Total hip BMD. B, Spine BMD. C, Whole body BMD.