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Article |

Parent Opinions About Universal Influenza Vaccination for Infants and Toddlers FREE

Sharon G. Humiston, MD, MPH; E. Brooke Lerner, PhD; Elizabeth Hepworth, BA; Taura Blythe, MD; Julius G. Goepp, MD
[+] Author Affiliations

Author Affiliations: Department of Emergency Medicine (Drs Humiston, Lerner, and Blythe and Ms Hepworth), University of Rochester School of Medicine and Dentistry and Lupine Creative Consulting (Dr Goepp), Rochester, NY.


Arch Pediatr Adolesc Med. 2005;159(2):108-112. doi:10.1001/archpedi.159.2.108.
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Published online

Background  Parent and caregiver opinions on the feasibility of routine influenza vaccinations for infants and toddlers are unknown.

Objective  To assess among English-speaking caregivers of children aged 6 to 23 months opinions about childhood influenza vaccination and potential knowledge, attitudinal, and demographic factors that might influence such opinions.

Methods  A structured, interviewer-administered survey of knowledge, attitudes, and beliefs about the influenza vaccine among parents and caregivers of children at the ambulatory pediatric clinic or the pediatric emergency department of a large tertiary care teaching hospital. The dependent measure was respondents’ expressed intentions to have their eligible children immunized against influenza in the upcoming season.

Results  We interviewed 153 caregivers. One hundred nineteen (78%) expressed intent to immunize. Safety was reported by 70 respondents (46%) as their most important concern, followed by the belief that the influenza vaccine could itself cause influenza (31 respondents, 20%). Respondents who believed that influenza was serious, that the influenza vaccine does not cause disease, or that all babies should be immunized had greater intent to immunize than those who did not (85%, 87%, and 96% vs 66%, 66%, and 49%, respectively). Those who believed that vomiting was a symptom of influenza, who did not name any vaccine adverse effect, or who had high school or lower educational levels also had greater intent to immunize (87%, 89%, and 83% vs 66%, 69%, and 69%, respectively).

Conclusion  Knowledge, attitudes, beliefs, and educational levels each had an independent influence on parents’ intentions to vaccinate the child, whereas demographic factors other than education did not.

Figures in this Article

Because of the potential severity of influenza among otherwise healthy infants and toddlers15 and the availability of a safe and efficacious vaccine,6 the American Academy of Pediatrics and the Advisory Committee on Immunization Practices7 issued a new recommendation8 broadening the pool of children who should be routinely vaccinated. Under the new guideline, healthy children aged 6 to 23 months should be routinely vaccinated. (The previous recommendation was that these children be vaccinated “when feasible.”9)

Although widespread implementation of the new recommendation is anticipated to reduce the burden of disease, significant practical obstacles could hamper adherence to the guideline. With an estimated 5.5 million US children in the target age group,10 an annual immunization campaign represents a substantial undertaking. Because of annual variations in the predominant strain of the influenza virus,11 a new vaccine must be developed each year and be manufactured, distributed, and administered within a short window of opportunity during the fall and early winter months. For children younger than 9 years who receive the injectable vaccine for the first time, the Advisory Committee on Immunization Practices recommends that a second dose be given at least 4 weeks after the first.8 The majority of targeted children must therefore make 1 or 2 closely spaced visits to their primary care providers’ offices in a short time period. Because such visits would not otherwise happen,12 this requirement adds to the complexity of adhering to the guidelines.

Successful implementation of the new guidelines in the face of such substantial barriers will require a carefully planned campaign that incorporates a thorough knowledge not only of the biological science involved, but also of the knowledge base, attitudes, beliefs, and behaviors of the 2 main stakeholders involved: health care providers and families with children in the target population.

Although evidence indicates that many pediatricians and family practitioners have a positive attitude toward the new recommendations and believe that implementation is feasible,13 little is known about parents’ and caregivers’ opinions about the influenza vaccine. Parents have had a generally positive attitude toward other routine vaccinations but tend to believe that more vaccines are given than are needed.14 Such attitudes or beliefs might influence caregivers’ behaviors regarding the new recommendations and could impede successful implementation of the guidelines despite providers’ general enthusiasm for the vaccine. To better understand caregivers’ attitudes, we designed the current study with the objectives of assessing the following opinions among English-speaking caregivers of children aged 6 to 23 months:

  • Intention to provide influenza vaccination to their children.

  • Knowledge, attitudinal, and demographic factors that influence such opinions.

Subjects were the parents or caregivers of children who came for care at either the ambulatory pediatric clinic or the pediatric emergency department (PED) of a large tertiary care teaching hospital. All subjects were 18 years of age or older. Only caregivers who were parents or guardians of children aged 6 through 23 months were eligible. Caregivers were excluded from the study if the English-speaking interviewer felt that they did not have sufficient receptive and expressive language to communicate effectively with her or, in the PED, if the chief complaint indicated the need for exceptional urgency or privacy. The study interviewer conducted recruitment in the waiting room of the clinic and in individual examination rooms in the PED prior to evaluation by the attending physician. The clinic, but not the PED, was a routine site of influenza vaccine administration in this and previous seasons. This study was conducted June through August 2003, in anticipation of the upcoming influenza season and vaccine campaign.

We used a structured, interviewer-administered survey instrument. The instrument contained 28 items. Investigators constructed survey questions using expert opinion and prior experience. Individual questions were pretested among office staff members who had children in the target age group. Most of the basic demographic and socioeconomic information was elicited using multiple-choice questions. Respondent gender was sight-coded by the interviewer, and race and ethnicity were self-reported by respondents. The dependent measure, the respondents’ intentions to have their eligible children immunized in the upcoming season, was assessed with a single yes/no question, “If your child’s doctor recommends it this coming fall, would you have <this child> receive the influenza vaccine?” Knowledge about influenza and the influenza vaccine was assessed using a series of 3 true/false questions. Attitudes and beliefs about the influenza vaccine and vaccine programs were determined using ranking questions. Respondents were asked to rank sites that they felt were the most preferable for receiving the vaccine. Respondents were then read a list of some specific concerns that people might have about their children receiving the influenza vaccine and were asked to rank them in order of importance. Respondents indicated on a 5-point Likert scale which of a series of factors would directly influence their likelihood to have their children immunized. Respondents’ attitudes about the importance of immunizing all eligible children were measured with a single yes/no question.

A single trained interviewer conducted all of the interviews. The interviewer read the questions to the participants and recorded responses on the data sheet. The study was approved by the Research Subjects Review Board at the University of Rochester in the minimal risk category. This study’s intervention was the survey only. Survey studies benefit from assuring respondents that their anonymity is protected, and consent to the study is considered implicit in agreeing to be interviewed for the survey. For these reasons, no written consent for participation was obtained.

Descriptive statistics were generated for each survey question. Responses to 5-point Likert-scale questions about factors influencing likelihood to immunize were collapsed into dichotomous variables (likely/very likely and neutral/unlikely/very unlikely to influence a respondent to have the child immunized). Frequencies were calculated for likely/very likely responses.

Univariate statistical analyses were performed for each variable to determine its relationship to the dependent variable, the intention to have the eligible child immunized. We calculated odds ratios for variables having a statistically significant relationship with the dependent variable. We used logistic regression analysis to calculate adjusted odds ratios for each factor, controlling for any statistically significant demographic variables that might function as confounders (race, ethnicity, education, insurance status, income, gender, or site where the survey was conducted).

The interviewer approached 653 caregivers about the study; 451 (69%) agreed to participate. Of these, 290 did not meet all eligibility requirements (263 did not have a child in the target age range, 12 did not speak English, 6 participated previously, 4 were not parents or legal guardians, 3 were minors, and 2 were bringing their children because of sexual abuse). The survey was completed by 153 (95%) of the remaining 161 respondents. Their data (53 from the PED; 100 from the clinic) form the basis of our analysis.

Table 1 presents the demographics of the respondents according to the survey site. Clinic respondents had higher proportions of minority race and Hispanic ethnicity, with lower educational levels and reported household incomes, than did PED respondents. It was more common for index children of clinic respondents to be publicly insured than those of PED respondents. Overall, 63 (41%) of the adult respondents and 27 (18%) of their eligible children were reported as ever having had an influenza vaccine.

Table Graphic Jump LocationTable 1. Demographic Characteristics

The question measuring the dependent variable, the intentions to have their own children immunized this season, was answered affirmatively by 119 respondents (78%). Fewer (61%) believed that influenza is serious enough to have all children aged 6 to 23 months vaccinated. Figure 1 shows the Likert-scale responses grouped in order of the frequency of their being ranked likely/very likely to influence the respondent to immunize his or her child.

Place holder to copy figure label and caption
Figure 1.

The proportions of respondents who said that they would be likely or very likely to have their children immunized in the upcoming influenza season if each factor shown were true.

Graphic Jump Location

The proportion of all respondents who answered true for the statement “Influenza vaccine can cause influenza” was 49%. It was 56% for “One of the main symptoms of influenza is vomiting” and 63% for “Many babies who catch influenza need to be treated in the hospital.”

The majority of respondents (94%) listed the physician office or clinic as the first choice of site for receiving the vaccine. Three percent listed public health clinics, 2% listed school, and 1% listed grocery stores as their first choice.

Figure 2 shows concerns about the vaccine as the proportion of respondents ranking each proposed concern as most important. Safety was overwhelmingly the most common primary concern, reported by 46% of respondents, followed by the belief that the influenza vaccine could itself cause influenza (20%).

Place holder to copy figure label and caption
Figure 2.

The proportions of respondents who listed each factor shown as their primary concern about having their children receive the influenza vaccine.

Graphic Jump Location

When asked to name possible adverse effects of the influenza vaccine, 43% of respondents indicated none or “don’t know.” The most commonly listed adverse effects were fever (20%), the belief that the vaccine could cause influenza itself (11%), allergy (5%), and “getting sick” (4%). Nineteen other possible adverse effects were each listed by less than 3% of respondents.

Table 2 shows odds ratios for each dichotomous variable that had a statistically significant relationship with the dependent variable on univariate analysis. Only 1 demographic variable (educational level) was significantly associated (negatively) with the intent to immunize. Adjusted odds ratios are shown, controlling for educational level; there was little change. There was no difference in the intention to immunize based on survey site (clinic or PED).

Table Graphic Jump LocationTable 2. Odds Ratios for Respondent Intent to Immunize the Eligible Child by Response to Survey Questions

Little is known about parents’ and other caregivers’ knowledge, attitudes, and beliefs about influenza disease, the influenza vaccination, and their relationships to the new recommendations. The results of the present study suggest that parents’ and caregivers’ knowledge about influenza and the vaccine, attitudes about adverse effects, and beliefs that infants in general should be immunized against influenza independently and significantly influenced their expressed intentions to immunize an at-risk child. We also found that the caregivers’ educational level had an independent effect on the intention to immunize: those with less than a college degree were more likely to intend to immunize their children. Educational level did not, however, affect responses to the other independent variables. Demographic variables other than educational level were found to have no impact on caregivers’ expressed intentions to immunize. Safety and the erroneous idea that the vaccine can cause influenza headed the respondents’ lists of concerns about influenza immunization. The most commonly ranked factors that respondents said would influence them to seek immunization were the prevention of ear infections, a no-cost vaccine, and having fewer safety concerns. Respondents ranked a moderate cost and other practical factors relatively low, in contrast with a recent survey of provider opinions13 in which costs, vaccine safety issues, and the inability to identify eligible children were most frequently cited as important potential barriers for practices to immunize children.

It is perhaps not surprising to find that the intention to immunize appears to be related to parents’ understanding the seriousness of influenza and the safety and adverse effects of the vaccine. This finding would also partly explain the relatively low importance placed by respondents on practical aspects of obtaining the vaccine: a concerned and motivated caregiver would be less troubled by the number of vaccines, frequent trips to the doctor, or a moderate cost. In contrast with what is known about the strong influence of race on adult influenza immunization rates,15 our finding that significant demographic associations (other than educational level) did not influence the intentions might also be attributable to the degree to which parents’ concerns and motivations help them overcome barriers imposed by their social locations.16 It is of course equally possible that expressed intent to immunize and actual immunization rates will differ along demographic lines.

This study’s findings can be incorporated into specific approaches to increasing vaccination rates. Physicians and health educators should focus on amplifying caregivers’ existing knowledge of the seriousness of influenza among young children and on enhancing their understanding of the safety and the low rate of adverse effects from the vaccine. Physicians and educators should pay particular attention to combating the myth that the vaccine itself can cause influenza, a particularly troubling finding. Although health care providers surveyed previously13 emphasized practicality and convenience, our findings suggest that improving those factors for caregivers is not likely to substantially enhance immunization rates. Provider time and resources might be better directed at educational and safety concerns. This study was conducted before the widely publicized deaths during the 2003-2004 season17 and the vaccine shortage being experienced in the current season. Our data suggest that these 2 events will reinforce in the public mind the seriousness of influenza and the importance of obtaining prompt immunization for vulnerable populations.

LIMITATIONS

This study’s results must be interpreted in the context of several methodological limitations, most of which might affect whether our findings can be generalized. The survey tool was pilot-tested for usability but was not rigorously tested for reliability or external validity. The survey was conducted in only 1 geographic location in the United States, so that regional variability was not controlled. The sample was limited to English-speaking respondents only, which has obvious implications for cultural bias. Although the use of a single interviewer obviated the possibility of interobserver reliability, it might have introduced other kinds of systematic bias related to gender, race, or culture. Situating the survey interview in a hospital setting might have induced pressures on subjects to provide “health care–friendly” responses, potentially masking significant reluctance to immunize. As has been found in other studies,18 many families approached in the PED refused to participate, which also might have biased results toward health care–friendly responses. The closed-ended nature of the structured survey instrument could have missed certain, more nuanced factors that might have real impact on the intent or likelihood to immunize. Finally, the relatively small sample size precluded any multivariate analysis that would be capable of determining the possible interactions between factors.

Among the respondents in this limited sample, confidence in the safety of the influenza vaccine and knowledge of its potential adverse effects were positively associated with intent to immunize children in the population targeted by the Advisory Committee on Immunization Practices’s new recommendations. In contrast with concerns expressed by health care providers, the cost and practicality of the increased number of vaccines were not identified as major potential barriers to immunizing young children. Demographic factors were not associated with the intent to immunize, with the exception of a negative association with educational level. Influenza vaccine campaigns aimed at consumers should focus on vaccine safety and on expanding the knowledge base about influenza disease among caregivers with children in the target age groups.

Correspondence: Sharon G. Humiston, MD, MPH, Department of Emergency Medicine, Box 655, 601 Elmwood Ave, Rochester, NY 14642 (sharon_humiston@urmc.rochester.edu).

Accepted for Publication: November 16, 2004.

Funding/Support: This work was supported by a research fund provided by the Ronald McDonald Children’s Charities.

Neuzil  KMWright  PFMitchel  EF  JrGriffin  MR The burden of influenza illness in children with asthma and other chronic medical conditions. J Pediatr 2000;137856- 864
PubMed Link to Article
Izurieta  HSThompson  WWKramarz  P  et al.  Influenza and the rates of hospitalization for respiratory disease among infants and young children. N Engl J Med 2000;342232- 239
PubMed Link to Article
Neuzil  KMMellen  BGWright  PFMitchel  EF  JrGriffin  MR The effect of influenza on hospitalizations, outpatient visits, and courses of antibiotics in children. N Engl J Med 2000;342225- 231
PubMed Link to Article
Neuzil  KMZhu  YGriffin  MR  et al.  Burden of interpandemic influenza in children younger than 5 years. J Infect Dis 2002;185147- 152
PubMed Link to Article
Iwane  MKEdwards  KMSzilagyi  PG  et al.  Population-based surveillance for hospitalizations associated with respiratory syncytial virus, influenza virus, and parainfluenza viruses among young children. Pediatrics 2004;1131758- 1764
PubMed Link to Article
Neuzil  KMDupont  WDWright  PFEdwards  KM Efficacy of inactivated and cold-adapted vaccines against influenza A infection, 1985 to 1990: the pediatric experience. Pediatr Infect Dis J 2001;20733- 740
PubMed Link to Article
American Academy of Pediatrics Committee on Infectious Diseases, Recommendations for influenza immunization of children. Pediatrics 2004;1131441- 1447
PubMed Link to Article
Harper  SAFukuda  KUyeki  TMCox  NJBridges  CBCenters for Disease Control and Prevention (CDC) Advisory Committee on Immunization Practices (ACIP), Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2004;53(RR-6)1- 40
PubMed
Bridges  CBFukuda  KUyeki  TMCox  NJSingleton  JACenters for Disease Control and Prevention, Advisory Committee on Immunization Practices, Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2002;51(RR-3)1- 31
PubMed
US Census Bureau, Quarterly Projections of the Resident Population by Age, Sex, Race, and Hispanic Origin: Middle Series, January 1, 1999 to January 1, 2101.  Washington, DC US Census Bureau2000;
Centers for Disease Control and Prevention, Update: influenza activity–United States and worldwide, 2003-04 season, and composition of the 2004-05 influenza vaccine. MMWR Morb Mortal Wkly Rep 2004;53547- 552
PubMed
Szilagyi  PGIwane  MKSchaffer  SJ  et al.  Potential burden of universal influenza vaccination of young children on visits to primary care practices. Pediatrics 2003;112821- 828
PubMed Link to Article
Humiston  SGSzilagyi  PGIwane  MK  et al.  The feasibility of universal influenza vaccination for infants and toddlers. Arch Pediatr Adolesc Med 2004;158867- 874
PubMed Link to Article
Gellin  BGMaibach  EWMarcuse  EK Do parents understand immunizations? Pediatrics 2000;1061097- 1102
PubMed Link to Article
Centers for Disease Control and Prevention, Racial/ethnic disparities in influenza and pneumococcal vaccination levels among persons aged > or = 65 years—United States, 1989–2001. MMWR Morb Mortal Wkly Rep 2003;52958- 962
PubMed
O'Malley  ASSheppard  VBSchwartz  MMandelblatt  J The role of trust in use of preventive services among low-income African-American women. Prev Med 2004;38777- 785
PubMed Link to Article
Centers for Disease Control and Prevention, Update: influenza-associated deaths reported among children aged <18 years—United States, 2003–04 influenza season. MMWR Morb Mortal Wkly Rep 2004;521286- 1288
PubMed
Wilets  IO’Rourke  MNassisi  D How patients and visitors to an urban emergency department view clinical research. Acad Emerg Med 2003;101081- 1085
PubMed Link to Article

Figures

Place holder to copy figure label and caption
Figure 1.

The proportions of respondents who said that they would be likely or very likely to have their children immunized in the upcoming influenza season if each factor shown were true.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

The proportions of respondents who listed each factor shown as their primary concern about having their children receive the influenza vaccine.

Graphic Jump Location

Tables

Table Graphic Jump LocationTable 1. Demographic Characteristics
Table Graphic Jump LocationTable 2. Odds Ratios for Respondent Intent to Immunize the Eligible Child by Response to Survey Questions

References

Neuzil  KMWright  PFMitchel  EF  JrGriffin  MR The burden of influenza illness in children with asthma and other chronic medical conditions. J Pediatr 2000;137856- 864
PubMed Link to Article
Izurieta  HSThompson  WWKramarz  P  et al.  Influenza and the rates of hospitalization for respiratory disease among infants and young children. N Engl J Med 2000;342232- 239
PubMed Link to Article
Neuzil  KMMellen  BGWright  PFMitchel  EF  JrGriffin  MR The effect of influenza on hospitalizations, outpatient visits, and courses of antibiotics in children. N Engl J Med 2000;342225- 231
PubMed Link to Article
Neuzil  KMZhu  YGriffin  MR  et al.  Burden of interpandemic influenza in children younger than 5 years. J Infect Dis 2002;185147- 152
PubMed Link to Article
Iwane  MKEdwards  KMSzilagyi  PG  et al.  Population-based surveillance for hospitalizations associated with respiratory syncytial virus, influenza virus, and parainfluenza viruses among young children. Pediatrics 2004;1131758- 1764
PubMed Link to Article
Neuzil  KMDupont  WDWright  PFEdwards  KM Efficacy of inactivated and cold-adapted vaccines against influenza A infection, 1985 to 1990: the pediatric experience. Pediatr Infect Dis J 2001;20733- 740
PubMed Link to Article
American Academy of Pediatrics Committee on Infectious Diseases, Recommendations for influenza immunization of children. Pediatrics 2004;1131441- 1447
PubMed Link to Article
Harper  SAFukuda  KUyeki  TMCox  NJBridges  CBCenters for Disease Control and Prevention (CDC) Advisory Committee on Immunization Practices (ACIP), Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2004;53(RR-6)1- 40
PubMed
Bridges  CBFukuda  KUyeki  TMCox  NJSingleton  JACenters for Disease Control and Prevention, Advisory Committee on Immunization Practices, Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2002;51(RR-3)1- 31
PubMed
US Census Bureau, Quarterly Projections of the Resident Population by Age, Sex, Race, and Hispanic Origin: Middle Series, January 1, 1999 to January 1, 2101.  Washington, DC US Census Bureau2000;
Centers for Disease Control and Prevention, Update: influenza activity–United States and worldwide, 2003-04 season, and composition of the 2004-05 influenza vaccine. MMWR Morb Mortal Wkly Rep 2004;53547- 552
PubMed
Szilagyi  PGIwane  MKSchaffer  SJ  et al.  Potential burden of universal influenza vaccination of young children on visits to primary care practices. Pediatrics 2003;112821- 828
PubMed Link to Article
Humiston  SGSzilagyi  PGIwane  MK  et al.  The feasibility of universal influenza vaccination for infants and toddlers. Arch Pediatr Adolesc Med 2004;158867- 874
PubMed Link to Article
Gellin  BGMaibach  EWMarcuse  EK Do parents understand immunizations? Pediatrics 2000;1061097- 1102
PubMed Link to Article
Centers for Disease Control and Prevention, Racial/ethnic disparities in influenza and pneumococcal vaccination levels among persons aged > or = 65 years—United States, 1989–2001. MMWR Morb Mortal Wkly Rep 2003;52958- 962
PubMed
O'Malley  ASSheppard  VBSchwartz  MMandelblatt  J The role of trust in use of preventive services among low-income African-American women. Prev Med 2004;38777- 785
PubMed Link to Article
Centers for Disease Control and Prevention, Update: influenza-associated deaths reported among children aged <18 years—United States, 2003–04 influenza season. MMWR Morb Mortal Wkly Rep 2004;521286- 1288
PubMed
Wilets  IO’Rourke  MNassisi  D How patients and visitors to an urban emergency department view clinical research. Acad Emerg Med 2003;101081- 1085
PubMed Link to Article

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