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The Pediatric Forum |

Sex Differences in Morbidity and Mortality Among Children With Perinatally Acquired Human Immunodeficiency Virus Infection in New York City

Kai-Lih Liu, PhD, MPH; Vicki Peters, MD; Jeremy Weedon, PhD; Pauline Thomas, MD; Kenneth Dominguez, MD, MPH
Arch Pediatr Adolesc Med. 2004;158(12):1187-1188. doi:10.1001/archpedi.158.12.1187.
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Studies on sex differences among adults with human immunodeficiency virus (HIV) have shown conflicting results. We sought to evaluate sex differences in morbidity and mortality among perinatally HIV-infected children. The study population included HIV-infected children born in 1990-1998 and enrolled in the Centers for Disease Control and Prevention (Atlanta, Ga)–funded the Pediatric Spectrum of HIV Disease project in 10 hospitals in New York City, NY. Medical records were reviewed every 6 months or until the child was no longer in care at the sites or died. All study children, stratified into 3 birth cohorts (1990-1992, 1993-1995, and 1996-1998), were evaluated for HIV infection within 3 months of birth.

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Figure.

Kaplan-Meier estimated survivals (A) and AIDS incidence (B) among children with perinatal human immunodeficiency virus (HIV) born 1990-1998 by sex and birth cohort, New York City, the Pediatric Spectrum of HIV Disease project. Because there was no significant difference in time to death and AIDS incidence between the 1990-1992 and 1993-1995 cohorts, the 1990-1995 and 1996-1998 cohorts were combined.

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