Functionally disabling chronic fatigue is a familiar complaint in adult primary care settings, infrequent among adolescents, and very rare in children. For more than a century, a syndrome of chronic fatigue associated with various physical and cognitive symptoms has been described with terms including neurasthenia, Akureyri disease, Royal Free disease, myalgic encephalomyelitis, postviral syndrome, and chronic fatigue syndrome (CFS). Scant data estimate that pediatric CFS has a prevalence ranging from 23 to 116 of 100 000 children and adolescents with an approximate 2.5:1 female to male ratio.1 Various diagnostic criteria have been proposed, but most researchers today use the 1994 Centers for Disease Control and Prevention (Atlanta, Ga) revised CFS criteria2 that require the presence of medically unexplained, profound, persistent or intermittent fatigue associated with significant functional disability for greater than 6 months and the presence of 4 additional symptoms (eg, headache, polyarthralgia, tender adenopathy, impaired memory). Those with at least 6 months of disabling fatigue but an insufficient number of symptoms to meet the Centers for Disease Control and Prevention CFS criteria have been labeled as having idiopathic chronic fatigue. While excluding most major psychiatric disorders, the Centers for Disease Control and Prevention criteria do allow some comorbid psychiatric symptoms, including anxiety and nonmelancholic depression, which may be problematic since both anxiety and depression have a well-established, independent relationship with fatigue.3
Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more
Subscribe for full-text access to content from 1998 forward and a host of useful features
Activate your current subscription (AMA members and current subscribers)
Purchase Online Access to this article for 24 hours
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
Thank you for submitting a comment on this article. It will be reviewed by JAMA Pediatrics editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 5
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
and access these and other features:
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.