This study has several limitations. First, the data are cross-sectional, which precludes our ability to infer causal relationships between the social environment and tobacco use. Prospective studies that examine how the social environment affects trajectories of tobacco use are needed to establish causal inferences. Second, this study was conducted in Oregon, which could restrict the generalizability of the results. Replication of these findings in other social contexts is, therefore, warranted. Third, the OHT survey is a school-based sample of youth; consequently, runaway and homeless youth were not sampled. Lesbian, gay, and bisexual individuals are overrepresented among homeless youth41; consequently, this study likely missed a vulnerable subpopulation of LGB youth. On the other hand, a negative social environment is likely to be an even stronger predictor of health-risk behaviors, including tobacco use, in LGB homeless youth. As such, noninclusion of homeless youth likely biased these results toward the null. Future studies are, therefore, needed to replicate these findings using samples of youth from diverse social contexts. Fourth, research from the National Longitudinal Study of Adolescent Health has indicated that the prevalence of tobacco use in sexual minority youth differs as a function of the operationalization of sexual orientation (ie, attraction, relationships, and self-identification).42,43 Because the OHT study assessed self-identification only, these results require replication with other measures of sexual orientation. Fifth, the OHT study does not release data on the specific schools that participated in the survey. The variables on school policies were, therefore, aggregated across the district level, which meant that they were less sensitive indicators than were measures of individual school policies. This likely reduced the power to detect a significant reduction in sexual orientation–related disparities in tobacco after adjusting for the measure of the social environment. Consequently, an important direction for future research is the development of ecologic measures that are more proximal to LGB youth (eg, neighborhoods), which will provide an opportunity to test the sensitivity of this study's results across different spatial scales.44 Nevertheless, the fact that we could document an association between social climate at the county level and tobacco use suggests that these results are likely conservative estimates of the effect of the social environment on the prevalence of smoking in LGB youth. Conversely, previous studies45,46 of “place effects” and the health of LGB populations have been conducted at the state level, and, thus, areas as small as counties may not reflect all aspects of the community climate.47 Future studies incorporating measures at multiple levels of place (state, county, neighborhood, and school) are important to comprehensively characterize the social environment in which youth are embedded.