A 7-week-old boy presented with recurrent blisters in a linear configuration on the left posterior leg that were first noted at 3 days of age. Bacitracin ointment had been previously applied with no improvement. During the preceding few weeks, newer, “warty” papules developed in the same distribution. The patient was born via normal spontaneous vaginal delivery at 38 weeks' gestation following a pregnancy complicated by polyhydramnios and an abnormal triple screen. A prenatal diagnosis of Klinefelter syndrome (47, XXY) had been made.