Home visiting by nurses for low-income, at-risk families has been promoted as a means of preventing child abuse and neglect, children's mental health problems, and adolescent crime. In this randomized controlled trial of the Nurse-Family Partnership among low-income women in Memphis, Tennessee, the investigators studied the impact of the program on the children. By the time the first-born child was aged 12 years, those visited by nurses, compared with those in the control group, reported fewer days of having used tobacco, alcohol, and marijuana and were less likely to report having internalizing disorders that met the clinical/borderline threshold. Nurse-visited children born to mothers with low psychological resources scored higher on achievement tests in reading and math. There were no statistically significant program effects on children's externalizing or total behavioral problems. These results support the hypothesis that the program will continue to affect children's health and behavior, as found in an earlier trial.